文献一覧: Yuko HASHIMOTO (著者)

20 0 0 0 OA Cytological examination of the thyroid in children and adolescents after the Fukushima Nuclear Power Plant accident: the Fukushima Health Management Survey

著者: Atsuhiko Sakamoto Takashi Matsuzuka Yukie Yamaya Satoru Suzuki Manabu Iwadate Satoshi Suzuki Yuko Hashimoto Osamu Suzuki Shinichi Suzuki Susumu Yokoya Tetsuya Ohira Seiji Yasumura Hitoshi Ohto Kenji Kamiya Hiroki Shimura
出版者: The Japan Endocrine Society
雑誌: Endocrine Journal (ISSN:09188959)
巻号頁・発行日: pp.EJ20-0235, (Released:2020-08-20)
被引用文献数: 1

The Fukushima Daiichi Nuclear Power Plant accident occurred on March 11 2011, following the Great East Japan Earthquake and tsunami. Radioactive materials, including I-131, were released into the environment after the accident. Shortly after, the prefectural government initiated the Fukushima Health Management Survey for monitoring the long-term health conditions of the residents of Fukushima Prefecture. In the survey, thyroid ultrasonography was scheduled for all people aged 18 years or younger who were living in Fukushima Prefecture at the time of disaster. The total number of examinees was approximately 370,000 in the Preliminary Baseline Survey (PBLS), and 380,000 in the first Full-scale Survey (FSS). First, thyroid ultrasonography was performed as the Primary Examination. When a thyroid nodule that meets the fine needle aspiration cytology (FNAC) guideline is detected, thyroid FNAC is performed. By the end of June 2017, the cytological specimens of 187 examinees had been interpreted as Malignant or Suspicious for Malignancy (SFM). In this article, the cytological results of whole categories are presented using the criteria of The Bethesda System for Reporting Thyroid Cytopathology. The total numbers of examinees with SFM or Malignant in PBLS and at the first FSS were 106 (62.0%) and 71 (38.0%), respectively. The data of the cytological results of SFM and Malignant were already reported. However, this is the first report of cytological data from categories other than SFM and Malignant. The results of the current study will contribute to future research into the thyroid conditions of children and adolescents.

2022-04-13 10:11:30
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6 0 0 0 OA Podoplanin promotes cell proliferation, survival, and migration of canine non-tonsillar squamous cell carcinoma

著者: Masahiro SHINADA Daiki KATO Masaya TSUBOI Namiko IKEDA Susumu AOKI Takaaki IGUCHI Toshio LI Yuka KODERA Ryosuke OTA Shoma KOSEKI Hayato SHIBAHARA Yosuke TAKAHASHI Yuko HASHIMOTO James CHAMBERS Kazuyuki UCHIDA Shunsuke NOGUCHI Yukinari KATO Ryohei NISHIMURA Takayuki NAKAGAWA
出版者: JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌: Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日: pp.23-0062, (Released:2023-08-04)
被引用文献数: 1

Podoplanin (PDPN) is a prognostic factor and is involved in several mechanisms of tumor progression in human squamous cell carcinoma (SCC). Canine non-tonsillar SCC (NTSCC) is a common oral tumor in dogs and has a highly invasive characteristic. In this study, we investigated the function of PDPN in canine NTSCC. In canine NTSCC clinical samples, PDPN overexpression was observed in 80% of dogs with NTSCC, and PDPN expression was related to ki67 expression. In PDPN knocked-out canine NTSCC cells, cell proliferation, cancer stemness, and migration were suppressed. As the mechanism of PDPN-mediated cell proliferation, PDPN knocked-out induced apoptosis and G2/M cell cycle arrest in canine NTSCC cells. These findings suggest that PDPN promotes tumor malignancies and may be a novel biomarker and therapeutic target for canine NTSCC.

2023-08-07 18:59:28
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6 0 0 0 OA Investigation of thyroid cancer cases that were not detected in the Thyroid Ultrasound Examination program of the Fukushima Health Management Survey but diagnosed at Fukushima Medical University Hospital

著者: Susumu Yokoya Manabu Iwadate Hiroki Shimura Satoru Suzuki Takashi Matsuzuka Satoshi Suzuki Shigeyuki Murono Seiji Yasumura Kenji Kamiya Yuko Hashimoto Shin-Ichi Suzuki
出版者: THE FUKUSHIMA SOCIETY OF MEDICAL SCIENCE
雑誌: FUKUSHIMA JOURNAL OF MEDICAL SCIENCE (ISSN:00162590)
巻号頁・発行日: pp.2019-26, (Released:2019-12-13)
参考文献数: 12
被引用文献数: 2

The Great East Japan Earthquake, which occurred on March 11, 2011, and its subsequent Fukushima Daiichi Nuclear Power Plant accident, prompted implementation of the Thyroid Ultrasound Examination (TUE) program as a part of the Fukushima Health Management Survey. The purpose of this program is to support residents of Fukushima Prefecture, and to analyze the health effects of the released radionuclides. Regardless of relatively high participation rates and a well-planned diagnostic flow, it is conceivable that not all thyroid cancer cases can be detected by the TUE program. The aims of the present study were to identify and characterize these “outside” cases, targeting patients at Fukushima Medical University (FMU) Hospital. As of June 30, 2017, we have successfully identified 11 outside cases. These corresponded to 5.7% of the 194 subjects who were identified as having thyroid cancer or suspected thyroid cancer in the TUE program. Although the outside subjects of other institutes were not investigated, the present study may have identified the majority of outside subjects in Japan, considering that FMU Hospital treats a large number of thyroid cancer subjects. Furthermore, the characteristics of the 11 subjects were not different from those of the subjects identified in the TUE program. These findings confirm that the TUE program was able to identify subjects of thyroid cancer adequately and sufficiently.

2020-08-24 14:27:35
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5 0 0 0 OA Investigation of thyroid cancer cases that were not detected in the Thyroid Ultrasound Examination program of the Fukushima Health Management Survey but diagnosed at Fukushima Medical University Hospital

著者: Susumu Yokoya Manabu Iwadate Hiroki Shimura Satoru Suzuki Takashi Matsuzuka Satoshi Suzuki Shigeyuki Murono Seiji Yasumura Kenji Kamiya Yuko Hashimoto Shin-Ichi Suzuki
出版者: THE FUKUSHIMA SOCIETY OF MEDICAL SCIENCE
雑誌: FUKUSHIMA JOURNAL OF MEDICAL SCIENCE (ISSN:00162590)
巻号頁・発行日: vol.65, no.3, pp.122-127, 2019 (Released:2020-01-09)
参考文献数: 12
被引用文献数: 2

2020-08-24 14:27:37
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4 0 0 0 OA Cytological examination of the thyroid in children and adolescents after the Fukushima Nuclear Power Plant accident: the Fukushima Health Management Survey

著者: Atsuhiko Sakamoto Takashi Matsuzuka Yukie Yamaya Satoru Suzuki Manabu Iwadate Satoshi Suzuki Yuko Hashimoto Osamu Suzuki Shinichi Suzuki Susumu Yokoya Tetsuya Ohira Seiji Yasumura Hitoshi Ohto Kenji Kamiya Hiroki Shimura
出版者: The Japan Endocrine Society
雑誌: Endocrine Journal (ISSN:09188959)
巻号頁・発行日: vol.67, no.12, pp.1233-1238, 2020 (Released:2020-12-28)
参考文献数: 30
被引用文献数: 1

2021-01-08 13:52:58
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3 0 0 0 OA Overexpression of human epidermal growth factor receptor 2 in canine primary lung cancer

著者: Sho YOSHIMOTO Daiki KATO Satoshi KAMOTO Kie YAMAMOTO Masaya TSUBOI Masahiro SHINADA Namiko IKEDA Yuiko TANAKA Ryohei YOSHITAKE Shotaro ETO Kohei SAEKI James CHAMBERS Yuko HASHIMOTO Kazuyuki UCHIDA Ryohei NISHIMURA Takayuki NAKAGAWA
出版者: JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌: Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日: pp.20-0026, (Released:2020-04-03)
被引用文献数: 6

Human epidermal growth factor receptor 2 (HER2) overexpression has been reported in various human cancers. HER2-targeted therapies showed clinical responses in humans with HER2-positive tumors. The incidence of canine primary lung cancer (cPLC) is increasing, but there are no effective systemic therapies for dogs with late-stage cPLC. HER2-targeted therapy could be an option for cPLC, but HER2 expression in cPLC remains unknown. We evaluated HER2 expression in cPLC. Immunohistochemical analysis revealed that 3 samples (19%) scored 3+; 8 (50%), 2+; 5 (31%); and 1+ and 0 (0%), 0. Of the cPLC tissues, 69% were HER2 positive (scored ≥2+). These data would lead to further evaluation of the role of HER2 in cPLC as a mechanism of malignancy and therapeutic target.

2020-04-04 07:13:07
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2 0 0 0 OA Detection of indoleamine 2,3-dioxygenase 1-expressing cells in canine normal and tumor tissues

著者: Namiko IKEDA Daiki KATO Masaya TSUBOI Ryohei YOSHITAKE Shotaro ETO Sho YOSHIMOTO Masahiro SHINADA Satoshi KAMOTO Yuko HASHIMOTO Yousuke TAKAHASHI James CHAMBERS Kazuyuki UCHIDA Ryohei NISHIMURA Takayuki NAKAGAWA
出版者: JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌: Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日: vol.83, no.12, pp.1885-1890, 2021 (Released:2021-12-02)
参考文献数: 27
被引用文献数: 1

Cancer immunotherapy is a novel cancer treatment for canine tumors. Indoleamine 2,3-dioxygenase 1 (IDO1) is overexpressed in some human tumors and inhibits antitumor immunity. In this study, we comprehensively evaluated expression pattern of IDO1 and the nature of IDO1-expressing cells in canine normal and tumor tissues. In normal tissue samples, IDO1 expression was detected only in the lymph nodes, spleen, tonsil tissues, and colon tissues. In contrast, IDO1-positive tumor cells were observed in several tumor tissue types. This is the first study to evaluate IDO1 expression in canine normal and tumor tissues, and the results suggest that IDO1 is a promising target for novel cancer immunotherapy in dogs with tumors.

2022-12-24 09:57:50
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1 0 0 0 OA Rapid Clinical Improvement of Multicentric Castleman Disease (MCD) with Renal Involvement Following Treatment with Tocilizumab: AA Amyloidosis as a Possible Renal Involvement of MCD

著者: Jumpei Temmoku Tomomi Sasajima Takeshi Kuroda Yuya Sumichika Kenji Saito Shuhei Yoshida Haruki Matsumoto Yuya Fujita Naoki Matsuoka Tomoyuki Asano Shuzo Sato Toshiyuki Yamada Yuko Hashimoto Kiyoshi Migita
出版者: Tohoku University Medical Press
雑誌: The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日: pp.2023.J003, (Released:2023-01-19)

2023-01-20 07:18:38
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1 0 0 0 OA Introduction of histological classification and cytology reporting format of the Japanese General Rules for the Description of Thyroid Cancer with a special focus on the differences of the WHO Histological Classification and The Bethesda System of Thyroid Cytology

著者: Atsuhiko Sakamoto Mitsuyoshi Hirokawa Masahiro Ito Hiroshi Naganuma Osamu Suzuki Yuko Hashimoto Shinichi Suzuki Hiroki Shimura
出版者: The Japan Endocrine Society
雑誌: Endocrine Journal (ISSN:09188959)
巻号頁・発行日: vol.68, no.6, pp.621-630, 2021 (Released:2021-06-28)
参考文献数: 22
被引用文献数: 6

Histological classification and cytology reporting format described in General Rules for the Description of Thyroid Cancer, the 8th edition (2019) (the Japanese General Rules) were briefly introduced. Moreover, the differences between “the Japanese General Rules”, and WHO Histological Classification, the 4th edition (2017) and The Bethesda System for Reporting Thyroid Cytopathology, the 2nd edition (2018) were also explained. The Japanese General Rules did not accept the borderline lesions of thyroid tumor which were newly shown in WHO Histological Classification. We believe it is not necessary to introduce these borderline lesions in daily practice in Japan. Borderline lesions were proposed for avoiding over-surgery for thyroid cancer patients. In the United States, when the patient is diagnosed as malignant on cytology, total thyroidectomy is generally recommended. However, there is no over-surgery in Japan, because surgeons have several choices of treatment for thyroid cancer patients. This article is the first that the Japanese General Rules was shown by foreign language. Therefore, this will be advantageous to us when we present our opinion concerning histology and cytology of thyroid tumor to the world.

2022-06-08 09:07:20
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1 0 0 0 OA Expression of podoplanin in various types of feline tumor tissues

著者: Satoshi KAMOTO Masahiro SHINADA Daiki KATO Masaya TSUBOI Sho YOSHIMOTO Ryohei YOSHITAKE Shotaro ETO Namiko IKEDA Yosuke TAKAHASHI Yuko HASHIMOTO James CHAMBERS Kazuyuki UCHIDA Shinji YAMADA Mika K. KANEKO Ryohei NISHIMURA Yukinari KATO Takayuki NAKAGAWA
出版者: JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌: Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日: vol.83, no.11, pp.1795-1799, 2021 (Released:2021-11-24)
参考文献数: 37
被引用文献数: 2

Podoplanin is expressed in various human tumors where it promotes tumor progression, epithelial-mesenchymal transition, and distant metastasis. Podoplanin is also expressed in cancer-associated fibroblasts and induces tumor malignancy. The objective of this study was to evaluate podoplanin expression in various types of feline tumor tissues. Immunohistochemical analysis revealed that podoplanin was expressed in cells of 13/15 (87%) squamous cell carcinomas and 5/19 (26%) fibrosarcomas. Moreover, cancer-associated fibroblasts expressed podoplanin in most tumor types, including 18/21 (86%) mammary adenocarcinoma tissues. Our findings demonstrate that various types of feline tumor tissues expressed podoplanin, indicating the importance of the comparative aspects of podoplanin expression, which may be used as a novel research model for podoplanin biology.

2021-12-04 00:59:58
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1 0 0 0 OA Detection of indoleamine 2,3-dioxygenase 1–expressing cells in canine normal and tumor tissues

著者: Namiko IKEDA Daiki KATO Masaya TSUBOI Ryohei YOSHITAKE Shotaro ETO Sho YOSHIMOTO Masahiro SHINADA Satoshi KAMOTO Yuko HASHIMOTO Yousuke TAKAHASHI James CHAMBERS Kazuyuki UCHIDA Ryohei NISHIMURA Takayuki NAKAGAWA
出版者: JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌: Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日: pp.21-0217, (Released:2021-10-22)
被引用文献数: 1

2021-10-27 11:00:28
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1 0 0 0 OA Expression of podoplanin in various types of feline tumor tissues

著者: Satoshi KAMOTO Masahiro SHINADA Daiki KATO Masaya TSUBOI Sho YOSHIMOTO Ryohei YOSHITAKE Shotaro ETO Namiko IKEDA Yosuke TAKAHASHI Yuko HASHIMOTO James CHAMBERS Kazuyuki UCHIDA Shinji YAMADA Mika K. KANEKO Ryohei NISHIMURA Yukinari KATO Takayuki NAKAGAWA
出版者: JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌: Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日: pp.20-0608, (Released:2021-10-18)
被引用文献数: 2

2021-10-20 10:24:11
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1 0 0 0 OA Obesity and low back pain: a retrospective cohort study of Japanese males

著者: Yuko Hashimoto Ko Matsudaira Susumu S. Sawada Yuko Gando Ryoko Kawakami Chihiro Kinugawa Takashi Okamoto Koji Tsukamoto Motohiko Miyachi Hisashi Naito
出版者: 理学療法科学学会
雑誌: Journal of Physical Therapy Science (ISSN:09155287)
巻号頁・発行日: vol.29, no.6, pp.978-983, 2017 (Released:2017-06-07)
参考文献数: 21
被引用文献数: 24

[Purpose] This study evaluated whether obesity is a risk factor for low back pain, by using body fat percentage (%FAT) and body mass index (BMI) as indices of obesity among Japanese males. [Subjects and Methods] This study included 1,152 males (average age: 28.0 ± 4.6 years). BMI was calculated from subject’s height and weight, and %FAT was estimated by the thickness of two parts of skin. Low back pain, drinking and smoking were surveyed using a self-administered questionnaire, and maximal oxygen uptake was measured by a submaximal exercise test using a cycle ergometer. [Results] A significant positive dose-response relationship was shown between %FAT and persistent low back pain prevalence. Similarly, a significant positive dose-response relationship was confirmed between BMI and persistent low back pain. [Conclusion] This study suggests that both high %FAT and BMI are risk factors for persistent low back pain.

2017-11-02 01:36:42
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