著者

Mei-Ling Chen Jung-Lun Wu Michael Yu-Chih Chen Tsung-Cheng Hsieh

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-18-1304, (Released:2019-04-23)

参考文献数

32

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Background:Data on clinical outcome after drug-eluting stent (DES) vs. bare-metal stent (BMS) implantation in patients with end-stage renal disease (ESRD) under hemodialysis are limited and controversial.Methods and Results:We identified 4,970 patients under chronic hemodialysis from Taiwan National Health Insurance Research Database (NHIRD) who had their first coronary stenting between 1 January 2007 and 31 December 2012. After 1:1 propensity score matching, we evaluated clinical outcomes for 1,151 patients in the DES group and 1,151 patients in the matched BMS group. We used ICD-9 CM codes or operation code to identify all outcomes in the study cohort after the index procedure. Primary outcomes including composite endpoints of mortality, non-fatal myocardial infarction (MI), non-fatal stroke, and revascularization after the index procedure were similar in both groups (HR, 0.94; 95% CI: 0.81–1.09; P=0.399). The results were consistent in various generations of DES vs. BMS groups. Secondary outcomes including mortality, non-fatal MI, non-fatal stroke, revascularization, cardiovascular death, hospitalization for heart failure, peptic ulcer bleeding or blood transfusion were similar in both groups, except for a lower risk of peptic ulcer disease in the DES group (HR, 0.59; 95% CI: 0.41–0.83; P=0.003) than the BMS group.Conclusions:In patients on chronic hemodialysis, implantation of DES did not have a better clinical outcome than BMS.

著者

Shih-Hu Ho Chia-Zong Lin Yu-Chih Chen Yen-Ling Song

出版者

The Japanese Society of Fish Pathology

雑誌

魚病研究 (ISSN:0388788X)

巻号頁・発行日

vol.37, no.1, pp.7-12, 2002-03-15 (Released:2009-10-26)

参考文献数

34

被引用文献数

1

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Vivrio hareyi など12種類のグラム陰性魚介類病原細菌およびオニテナガエビ寄生真菌1種類に対するセクロピンAとP1の抗菌性を調べた。 その結果, ほとんどの菌種に発育阻止効果を示し, セクロピンAの最小発育阻止濃度は0.98-7.81μM, 最小殺菌濃度(MBC)は3.90-15.59μmであった。 しかし塩分存在下(0.5M NaCl)では抗菌作用は低下した。 セクロピンAはウシエビの血球に対し, MBC値の3.2倍の濃度で細胞毒性を示した。 以上の結果から, セクロピンを海水飼育エビの細菌病に応用するのは難しいと考えられた。