- 著者
- Yoshimasa Sugiura Shouta Misumi Yoichi Kinoshita Hiroaki Yamatani Kazuma Yoshizumi Hirotaka Katsuzaki Yuichi Hayashi Noboru Murase
- 出版者
- Japanese Society for Food Science and Technology
- 雑誌
- Food Science and Technology Research (ISSN:13446606)
- 巻号頁・発行日
- pp.FSTR-D-23-00153, (Released:2023-12-25)
We investigated the antiallergic effects of 80 % methanol (80M) extracts obtained from Ecklonia cava subsp. stolonifera, harvested along the coast of Nishinoshima Town, Oki Islands, Shimane Prefecture, Japan, at different stages of algal powder manufacturing (involving heating operations). The radical-scavenging activity of the extracts increased during the manufacturing process. The extracts could mitigate allergic inflammation in mice and degranulation in rat basophilic leukemia-2H3 cells. The contents of typical algal polyphenols, such as phlorotannins (eckol, 6,6′-bieckol, 8,8′-bieckol, dieckol, and phlorofucofuroeckol-A), in the 80M extracts were analyzed via high-performance liquid chromatography and liquid chromatography-mass spectrometry, which revealed that eckol and dieckol were more abundant than the other three phlorotannins throughout the manufacturing process, while an increasing trend in the contents of all five phlorotannins was observed in later stages of the manufacturing process. Furthermore, measurement of the total polyphenol content revealed the probability of polyphenol polymerization during manufacture.
- 著者
- Takuya Kudo Akio Kimura Kazuhiro Higashida Megumi Yamada Yuichi Hayashi Takayoshi Shimohata
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- pp.5074-20, (Released:2020-07-14)
- 参考文献数
- 15
- 被引用文献数
- 1 7
We report a 65-year-old man with autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A) who presented with gait disturbance that he had experienced for approximately half a year. On neurological examination, he displayed spastic paraplegia and autonomic dysfunctions including dysuria and constipation. Spinal cord magnetic resonance imaging showed longitudinally extensive spinal cord lesions (LESCLs) extending from the cervical to the thoracic cords. The patient was negative for anti-myelin oligodendrocyte glycoprotein and anti-aquaporin 4 antibodies. Treatment with corticosteroids and intravenous immunoglobulin resulted in a clinical improvement. It is important to distinguish GFAP-A from slowly progressive myelitis with LESCLs.