- 著者
- Junko Sato Sachio Suzuki Makoto Sasaki Toshiharu Otaka Mizuho Aoi Yuji Uchida
- 出版者
- The Japanese Society for Neuroendovascular Therapy
- 雑誌
- Journal of Neuroendovascular Therapy (ISSN:18824072)
- 巻号頁・発行日
- pp.oa.2020-0118, (Released:2021-01-06)
- 参考文献数
- 19
- 被引用文献数
- 3
Objective: The aim of the present study was to evaluate the usefulness of the T2-weighted three-dimensional sequence method, known as “basi-parallel anatomical scanning (BPAS)-magnetic resonance imaging (MRI),” in demonstrating the running course of the obstructed middle cerebral artery (MCA) before acute mechanical thrombectomy.Methods: Patients whose M1 part and internal carotid artery (ICA) were occluded on preprocedural MRA, but well demonstrated on MCA anatomical scanning (MAS)-MRI were enrolled in this study. The MAS-MR images for patients in whom thrombectomy was performed were compared with the post-thrombectomy angiography. We compared the running course of the C1-M2 bifurcation on MAS-MRI and angiography after thrombectomy, and the results were classified into 3 groups (Excellent, Good, and Poor).Results: A total of 13 patients (range: 54–89) were enrolled, among whom 12 underwent thrombectomy. We compared MAS-MRI and post-thrombectomy angiography in 10. On comparison between MAS-MRI and post-procedural angiography, visualization was excellent in six (60%) patients. The mean age was 75.7 years, ranging from 54 to 89, and 6 were males. 3 patients had ICA occlusion and seven had MCA occlusion.Conclusion: MAS-MRI was considered useful to clarify the running course of the MCA before acute mechanical thrombectomy.
- 著者
- Yu Norikoshi Tokunori Ikeda Kodai Sasahara Mariko Hamada Erika Torigoe Mai Nagae Tomoe Tashiro Fukuko Horio Junji Saruwatari Yuji Uchida Makoto Anraku
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Biological and Pharmaceutical Bulletin (ISSN:09186158)
- 巻号頁・発行日
- vol.43, no.12, pp.1960-1965, 2020-12-01 (Released:2020-12-01)
- 参考文献数
- 27
- 被引用文献数
- 1
The novel anti-influenza virus agent baloxavir marboxil is a selective inhibitor of an influenza cap-dependent endonuclease. Although a single oral dose in tablet form of baloxavir marboxil is expected to improve drug compliance and rapidly reduce viral titers for pediatric patients with influenza, there is a concern that baloxavir marboxil-resistant influenza A variants could be generated. In this study, we investigated the frequency of prescription and pharmacy revisits for baloxavir marboxil at an outpatient clinic compared with that of neuraminidase inhibitors in pediatric patients with influenza. A total of 475 pediatric patients who were infected with the influenza virus visited the pharmacy between December 2019 and March 2020. Baloxavir marboxil (n = 149), oseltamivir (n = 161) and laninamivir (n = 162) were mainly prescribed and only a few patients were treated with peramivir (n = 2) or zanamivir (n = 1). Baloxavir marboxil-, oseltamivir- and laninamivir-treated pediatric patients were enrolled, and a log-rank test showed that the revisits of pediatric patients who were taking baloxavir marboxil was lower than those for oseltamivir (p < 0.001). Moreover, Cox proportional hazards models also revealed that baloxavir marboxil decreased the risk of revisits in comparison to oseltamivir (hazard ratio 0.28, 95% confidence interval 0.11–0.70, p = 0.006), while no difference was found between laninamivir and baloxavir marboxil. Although there is a need to acquire appropriate and relevant information concerning resistant viruses, our results suggest that baloxavir marboxil may be a useful drug for treating pediatric patients with influenza infections.
- 著者
- Junko Sato Sachio Suzuki Makoto Sasaki Toshiharu Otaka Mizuho Aoi Yuji Uchida
- 出版者
- The Japanese Society for Neuroendovascular Therapy
- 雑誌
- Journal of Neuroendovascular Therapy (ISSN:18824072)
- 巻号頁・発行日
- vol.15, no.7, pp.421-428, 2021 (Released:2021-07-20)
- 参考文献数
- 19
- 被引用文献数
- 3
Objective: The aim of the present study was to evaluate the usefulness of the T2-weighted three-dimensional sequence method, known as “basi-parallel anatomical scanning (BPAS)-magnetic resonance imaging (MRI),” in demonstrating the running course of the obstructed middle cerebral artery (MCA) before acute mechanical thrombectomy.Methods: Patients whose M1 part and internal carotid artery (ICA) were occluded on preprocedural MRA, but well demonstrated on MCA anatomical scanning (MAS)-MRI were enrolled in this study. The MAS-MR images for patients in whom thrombectomy was performed were compared with the post-thrombectomy angiography. We compared the running course of the C1-M2 bifurcation on MAS-MRI and angiography after thrombectomy, and the results were classified into 3 groups (Excellent, Good, and Poor).Results: A total of 13 patients (range: 54–89) were enrolled, among whom 12 underwent thrombectomy. We compared MAS-MRI and post-thrombectomy angiography in 10. On comparison between MAS-MRI and post-procedural angiography, visualization was excellent in six (60%) patients. The mean age was 75.7 years, ranging from 54 to 89, and 6 were males. 3 patients had ICA occlusion and seven had MCA occlusion.Conclusion: MAS-MRI was considered useful to clarify the running course of the MCA before acute mechanical thrombectomy.