著者

Kazuoki Dai Nobuo Shiode Kanade Yoshii Yuka Kimura Keita Matsuo Yusuke Jyuri Shunsuke Tomomori Tadanao Higaki Kuniomi Oi Tomoharu Kawase Akinori Sairaku Norihiko Ohashi Kazuyoshi Suenari Kenji Nishioka Yoshiko Masaoka Yukiko Nakano

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-23-0221, (Released:2023-06-01)

参考文献数

37

被引用文献数

1

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Background: Lipoprotein (a) (Lp(a)) is a complex circulating lipoprotein, and there is increasing evidence it is a risk factor for atherosclerotic cardiovascular disease (ASCVD). This study aimed to investigate the influence of Lp(a) serum levels on long-term outcomes after acute myocardial infarction (AMI).Methods and Results: Between January 2015 and January 2018, we enrolled 262 patients with AMI who underwent coronary angiography within 24 h of the onset of chest pain and had available Lp(a) data enabling subdivision into 2 groups: high Lp(a) (≥32 mg/dL: n=76) and low Lp(a) (<32 mg/dL: n=186). The primary endpoint was major adverse cardiac events (MACE), which was defined as a composite of cardiac death, nonfatal MI, and readmission for heart failure. Multivariate Cox regression analysis was performed to identify the predictors of MACE. The incidence of MACE was significantly higher in the high Lp(a) group than in the low Lp(a) group (32.8% vs. 19.6%, P=0.004). Multivariate analysis showed that Lp(a) ≥32 mg/dL was an independent predictor of MACE (hazard ratio 2.84, 95% confidence interval 1.25–6.60, P=0.013).Conclusions: High Lp(a) levels were associated with worse long-term outcomes after AMI, so Lp(a) may be useful for risk assessment.

著者

Munehiro YOSHIDA Yuka KIMURA Mamiko ABE Tatsuhiko ANDO Hiroshi TACHI Kenji FUKUNAGA

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.47, no.3, pp.248-252, 2001 (Released:2009-04-28)

参考文献数

19

被引用文献数

5 7

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For determination of selenium (Se) in biological materials, an improved method based on high performance liquid chromatographic determination of the fluo-rophore formed by reaction of selenite with 2, 3-diaminonapththalene was developed. The concentration detection limits were 0.5 ng/g in dried materials and 0.03 ng/mL in fluid ma-terials. In quadruplicate assays of 11 biological reference materials using the proposed method, measured Se concentrations were not significantly different from their certified val-ues, Thus, the proposed method is reliable and suitable for the determination of trace levels of Se in foods. Using the proposed method, Se concentrations in various kinds of tea were de-termined to assess the contribution of tea to daily Se intake in the Japanese population. Se concentration in the leaves of general black, green and oolong tea obtained in local retail stores was 33±19 ng/g (n=40). The leaves of a particular Chinese green tea sold under the name “high Se tea” were found to contain 455±184 ng/g (n=14) of Se. While the percent-age of Se extractable by infusion was less than 5% for the general teas, that in the high Se tea was more than 20%. These results indicated that intake of tea does not contribute to daily Se intake in the Japanese population. However, since infusions from high Se tea con-tained over 5 ng/mL of Se, consumption of over 1 L/d of tea derived from such high Se teas may increase the daily Se intake by close to 10%.