著者

Yuki Kimura Masato Nikaido

出版者

The Genetics Society of Japan

雑誌

Genes & Genetic Systems (ISSN:13417568)

巻号頁・発行日

pp.23-00188, (Released:2023-10-17)

参考文献数

28

---

Keratins are intermediate filament proteins that are important for epidermal strength and protection from desiccation. Keratin genes are highly duplicated and have diversified by forming two major clusters in the genomes of terrestrial vertebrates. The keratin genes of lungfishes, the closest fish to tetrapods, have not been studied at the genomic level, despite the importance of lungfishes in terrestrial adaptation. Here, we identified keratin genes in the genomes of two lungfish species and performed syntenic and phylogenetic analyses. Additionally, we identified keratin genes from two gobies and two mudskippers, inhabiting underwater and terrestrial environments. We found that in lungfishes, keratin genes were duplicated and diversified within two major clusters, similar to but independent of terrestrial vertebrates. By contrast, keratin genes were not notably duplicated in mudskippers. The results indicate that keratin gene duplication occurred repeatedly in lineages close to tetrapods, but not in teleost fish, even in species adapted to terrestrial environments.

著者

Naoki Murakami Kenji Yoshikawa Kohei Tsukada Noriaki Kamio Yoshinori Hayashi Suzuro Hitomi Yuki Kimura Ikuko Shibuta Ayaka Osada Shuichi Sato Koichi Iwata Masamichi Shinoda

出版者

Nihon University School of Dentistry

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

pp.21-0483, (Released:2021-12-29)

参考文献数

29

被引用文献数

1

---

Purpose: Periodontitis progresses with chronic inflammation, without periodontal pain. However, the underlying mechanisms are not well known. Here, the involvement of butyric acid (BA) in periodontal pain sensitivity in Porphyromonas gingivalis (P. gingivalis)-induced periodontitis was examined.Methods: P. gingivalis was inoculated into the ligature which was tied around the molar (P. gingivalis-L) and the gingival mechanical head withdrawal threshold (MHWT) was measured. Following P. gingivalis-L, the expressions of orphan G protein-coupled receptor 41 (GPR41) in trigeminal ganglion (TG) neurons were examined. The amount of gingival BA was analyzed following the P. gingivalis-L and the changes in the MHWT in complete Freund’s adjuvant (CFA)-injected gingival tissue by gingival BA were examined. The changes in the MHWT following P. gingivalis-L by gingival GPR41 antagonist (HA) were examined.Results: No change in the MHWT was observed, GPR41-immunoreactive TG neurons were increased following P. gingivalis-L. The gingival BA amount increased following P. gingivalis-L, and the gingival BA suppressed the decrease in MHWT following CFA. HA decreased MHWT following P. gingivalis-L.Conclusion: Gingival BA modulates periodontal mechanical nociception via GPR41 signaling in P. gingivalis-L-induced periodontitis.

著者

Yukiko Hirabayashi Haireti Alifu Dai Yamazaki ‪Gennadii Donchyts Yuki Kimura

出版者

Japan Society of Hydrology and Water Resources (JSHWR) / Japanese Association of Groundwater Hydrology (JAGH) / Japanese Association of Hydrological Sciences (JAHS) / Japanese Society of Physical Hydrology (JSPH)

雑誌

Hydrological Research Letters (ISSN:18823416)

巻号頁・発行日

vol.15, no.2, pp.37-43, 2021 (Released:2021-06-22)

参考文献数

23

---

Floods are major natural disasters that have considerable consequences worldwide. As the frequency and magnitude of flooding are expected to be affected by ongoing climate change, understanding their past changes is important for developing adequate adaptation measures. However, the limited spatiotemporal coverage of flood gauges hinders detection of changes in flooding, particularly in poorly gauged regions. Here, we propose a method using surface water data of river floodplain inundation as a proxy of the magnitude and frequency of flooding. Surface water data − Aqua Monitor which represented the probability linear trend changes in land and water surface area based on 30-m Landsat images between 1984–2000 and 2000–2013 was used in this study. The changes in water surface area over the floodplain obtained from Aqua Monitor showed high correspondence with historical trends observed or simulated annual maximum daily discharge, indicating the potential to detect changes in frequency and magnitude of flood from satellite data. In regions where changes could be measured with sufficient satellite images, 29% showed an increase in water surface area in the flood plain, 41% showed a decrease, and 30% showed small or no changes.

著者

Ken Tanaka Yuki Kimura Koichi Murayama

出版者

(社)日本化学会

雑誌

Bulletin of the Chemical Society of Japan (ISSN:00092673)

巻号頁・発行日

vol.88, no.3, pp.375-385, 2015-03-15 (Released:2015-03-15)

参考文献数

112

被引用文献数

113 5

---

The highly enantioselective synthesis of functionalized helicenes and helicene-like molecules have been achieved via rhodium-catalyzed [2+2+2] cycloaddition reactions. The rhodium-catalyzed enantioselective intramolecular [2+2+2] cycloaddition of 2-naphthol-linked triynes afforded [7]helicene-like molecules in good yields and ee values. The more sterically encumbered reaction, the rhodium-catalyzed enantioselective double intramolecular [2+2+2] cycloaddition of a 2-naphthol-linked hexayne, also proceeded to give a [11]helicene-like molecule with high ee value, although the product yield was low. Not only intramolecular cycloaddition reactions but also intermolecular ones were accomplished by combinations of electron-rich tetraynes and electron-poor diynes to give [7]- and [9]helicene-like molecules and [7]helicenes in varying yields and ee values.

著者

Kazuto MIYAWAKI Shigeki MORI Akira SAKURADA Akihiro NAGANAWA Yuki KIMURA Yotsugi SHIBUYA Goro OBINATA

出版者

一般社団法人 日本機械学会

雑誌

Journal of System Design and Dynamics (ISSN:18813046)

巻号頁・発行日

vol.5, no.4, pp.513-522, 2011 (Released:2011-06-20)

参考文献数

13

被引用文献数

1

---

Highly precise positioning control is based on mechatronics. Nanotechnology, especially nanometer positioning technology with high-speed and robust positioning feedback control, is used in various technical fields including measuring systems, magnetic recording and the semiconductor industry. To date, various actuator systems have been proposed, but the structural models have working distance of either less than a millimeter or more than ten millimeters. A structural model with working distance of several millimeters has not been reported in the relevant literature. We propose an actuator structural design that would enable production of actuator systems with such working distances. This actuator has a voice coil motor and a new guide with an elastic support mechanism consisting of a special spring that is restricted to movement in only one direction. This ESM causes no lost motion, friction with motion, or mechanical play. The voice coil motor thrusts and displaces the elastic support mechanism linearly. Therefore, highly precise positioning control can be realized using a simple controller. This paper describes evaluation of the positioning control method from the displacement of ESM and presents basic data for development of future nano-actuator systems.

著者

Yuki Kimura [ほか] [作] 高橋瑞木編

出版者

水戸芸術館現代美術センター

巻号頁・発行日

2011