著者

ABDUL SHAKOOR TATSUO MURAKAMI FUMIO YAMASHITA

出版者

久留米大学医学部

雑誌

The Kurume Medical Journal (ISSN:00235679)

巻号頁・発行日

vol.38, no.3, pp.211-220, 1991-11-01 (Released:2009-08-11)

参考文献数

21

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A study was undertaken to compare Pediatric Malignancy at Kurume (Japan) and Karachi (Pakistan) with reference to international data collected over the years, in order to identify essential differences between developed and developing conditions and factors influencing the etio-pathogenesis of pediatric cancer. The study was retrospective encompassing all types of cancer in children over a period of three years i-e 1988-1990. Essential factors related to present study were: 1. Population: The population of Karachi is about 10 million while that of Kurume is only half a million. 2. Socio-economic conditions: The average socioeconomic condition of people in Karachi is poor while in Kurume it appears to be good. 3. Educational status: Only 25% people in Karachi are educated beyond middle class while Kurume reveals a 100% education up to high school level. 4. Environmental conditions: The environmental conditions of Kurume and surrounding areas arevery clean and free from pollution, sewage problems and traffic hazards. Karachi and its surroundings on the other hand pose very serious air and water industries! It was concluded that whereas genetic predisposition predominates, the environmental conditions, educational and socio-economic status of a society immensely influence the pattern and trends of pediatric carcinogenesis.

著者

MASANAGA YOSHIMOTO

出版者

久留米大学医学部

雑誌

The Kurume Medical Journal (ISSN:00235679)

巻号頁・発行日

vol.31, no.2, pp.157-165, 1984-12-20 (Released:2009-08-11)

参考文献数

11

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We examined 20 episodes of nephrotic crisis (Cx) in 13 nephrotic children and report hematological findings and pathogenesis of the crisis. All physical and clinical data including serum and plasma protein levels and urinalysis, were recorded at the onset of Cx, during recovery and the interventing interval. There was a total of 20 incidences of Cx: 17 occurred at relapses and 3 at the onset of the nephrotic syndrome. We compare the Cx data with the data we additionally collected from 14 other children sufferring with nephrotic syndrome but without the complication of Cx (non-Cx) either at relapses (10) or first onset (4). The most characteristic Cx clinical manifestations (compared with non-Cx group) were abdominal pain in 85 % (cf. 14.3 %), vomiting in 70 % (cf. 0 %), and facial pallor in 65% (cf. 7.1 %). There were significant differences of the Cx clinical and hematological data when compared with the non-Cx data. The Cx group showed a significantly lower blood pressure, higher hematocrit value, lower serum sodium concentration, lower C3 level, lower CH50 activity and lower serum total protein and albumin (standardized for hematocrit values). We conclude that hypovolemia was the pathogenesis for Cx: the sudden loss of massive serum protein into urine, causing subsequent hypoproteinemia (hypoalbuminemia) and decreased colloidal osmotic pressure impairing re-entry transport of interstitial fluids from tissue to the blood. The hypovolemia of Cx is aggravated by the hyponatremia which arises due to a sodium shift from the blood to interstitial tissue. We investigated the role and mechanism of a possible hypoadrenocortical state and report negative findings in all cases.

著者

KAZUO SUENAGA KENJI GOTO HIDEFUMI SUENAGA

出版者

久留米大学医学部

雑誌

The Kurume Medical Journal (ISSN:00235679)

巻号頁・発行日

vol.14, no.2, pp.43-48, 1967-10-01 (Released:2009-08-11)

参考文献数

5

被引用文献数

2

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Working characteristics of the human body can be expressed by the pattern of mental activity because physical work is generally followed by conscious activity. When the mental work is classified as intermittent work and enduring mental work, driving should be classified as the latter. When driving, the central nervous system must continuously manage various types of stimuli (or information) arriving from circumstances of the roads. It was expected that these conditions would cause a difference in mental activity and hence EEG pattern between normal motorists and motorists who are frequently involved in traffic accidents. The state of appearance of alpha waves and the frequency of the alpha waves were comparatively investigated.