著者

Masaomi Nangaku Takashi Kadowaki Hiroshi Yotsuyanagi Norio Ohmagari Moritoki Egi Junichi Sasaki Tetsuya Sakamoto Yoshinori Hasegawa Takashi Ogura Shigeru Chiba Koichi Node Ryo Suzuki Yasuhiro Yamaguchi Atsuko Murashima Norihiko Ikeda Eriko Morishita Kenji Yuzawa Hiroyuki Moriuchi Satoshi Hayakawa Daisuke Nishi Atsushi Irisawa Toshiaki Miyamoto Hidetaka Suzuki Hirohito Sone Yuuji Fujino

出版者

Japan Medical Association / The Japanese Associaiton of Medical Sciences

雑誌

JMA Journal (ISSN:2433328X)

巻号頁・発行日

vol.4, no.2, pp.148-162, 2021-04-15 (Released:2021-05-07)

参考文献数

69

被引用文献数

7

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In 2020, the COVID-19 pandemic has had unprecedented impacts on various aspects of the world. Each academic society has published a guide and/or guidelines on how to cope with COVID-19 separately. As the one and only nationwide association of academic societies that represent medical science in Japan, JMSF has decided to publish the expert opinion to help patients and care providers find specifically what they want.This expert opinion is a summary of recommendations by many academic societies and will be updated when necessary. Patients that each academic society targets differ even though they suffer from the same COVID-19, and recommendations can be different in a context-dependent manner. Readers are supposed to be flexible and adjustable when they use this expert opinion.

著者

Akira Okada Hideo Yasunaga

出版者

Japan Medical Association / The Japanese Associaiton of Medical Sciences

雑誌

JMA Journal (ISSN:2433328X)

巻号頁・発行日

vol.5, no.2, pp.190-198, 2022-04-15 (Released:2022-05-16)

参考文献数

13

被引用文献数

8

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Introduction: Noncommunicable diseases (NCDs) are an ongoing public health problem globally. The present study aimed to estimate the prevalence of NCDs in Japan using a newly developed, commercially available administrative claims database covering young, middle-aged, and elderly people.Methods: We compared the age-stratified population distribution between the DeSC administrative claims database and the population estimates. We calculated the 1 year prevalence of several NCDs using the DeSC database and compared the prevalence of diabetes mellitus and hypertension between the DeSC database and the Japan National Health and Nutrition Survey.Results: The age distribution of the population included in the DeSC database was similar to that of the population estimates. The estimated prevalence rates were as follows: diabetes mellitus (12.2%), hypertension (20.9%), ischemic heart disease (5.6%), heart failure (5.3%), cerebral infarction (3.4%), stroke (3.7%), gastric cancer (0.6%), colorectal cancer (0.8%), breast cancer (1.5%), prostate cancer (0.6%), cataract (7.1%), depression (3.5%), and osteoporosis (6.3%). The estimated prevalence of diabetes and hypertension was comparable with that of the National Health and Nutrition Survey.Conclusions: The distribution of age and sex in the database was comparable with that of the population estimates. The prevalence of diabetes mellitus and hypertension was comparable with that in a previously reported national survey. Our data can be utilized as basic information for policymaking in clinical medicine and public health in Japan.

著者

Mitsuro Chiba Norikazu Morita Akira Nakamura Keisuke Tsuji Emiko Harashima

出版者

Japan Medical Association / The Japanese Associaiton of Medical Sciences

雑誌

JMA Journal (ISSN:2433328X)

巻号頁・発行日

vol.4, no.4, pp.347-357, 2021-10-15 (Released:2021-11-05)

参考文献数

57

被引用文献数

1

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Introduction: Inflammatory bowel disease has become a global disease, but its key environmental factors still remain unrecognized. This study aimed to clarify the role of dietary transition (westernization) in the increased incidence of inflammatory bowel disease in Japan.Methods: Annual numbers of new cases of inflammatory bowel disease in Japan over the period from 1965 to 2000 found in a nationwide database compiled by the government and the daily amount of food and nutrient intake per capita for the same period revealed by the National Nutrition Survey have been used to analyze their interrelation.Results: Rapid increases in the estimated incidence per 100,000 population have been observed, that is, from 0.08 in 1965 to 4.8 in 2000 for ulcerative colitis and from 0.003 to 1.3 in 2000 for Crohn's disease, with an extremely high correlation between the annual numbers of new cases of the respective diseases (r = 0.970). Intake of both animal fat and animal protein increased, while intake of rice decreased during the period. Of all food groups, the intake of rice as a staple food showed the highest negative correlation coefficient with the numbers of new cases of both ulcerative colitis (r = -0.825, 95% CI: -0.908 to -0.681, p < 0.0001) and Crohn's disease (r = -0.836, 95% CI: -0.914 to -0.700, p < 0.0001).Conclusions: An increased incidence of inflammatory bowel disease was observed to coincide with dietary westernization in Japan. Our results support the assertion that dietary westernization is a key environmental factor in inflammatory bowel disease.

著者

Hiroshi Kadowaki Hiroshi Akazawa Junichi Ishida Issei Komuro

出版者

Japan Medical Association / The Japanese Associaiton of Medical Sciences

雑誌

JMA Journal (ISSN:2433328X)

巻号頁・発行日

vol.4, no.2, pp.91-98, 2021-04-15 (Released:2021-05-07)

参考文献数

56

被引用文献数

11

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Onco-cardiology recently emerged as a novel discipline to provide effective cardioprotective care against cancer therapeutics-related cardiac adverse events (CAEs) and support the continuity of optimal cancer treatment. Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy and dramatically improved outcomes in patients with advanced or refractory cancers. However, ICIs intrinsically stimulate systemic immune responses and can potentially induce a spectrum of immune-related adverse events (irAEs), which can affect any organs of the body. The manifestation of cardiac irAEs includes myocarditis, arrhythmias and conduction abnormalities, and pericardial diseases. Takotsubo-like cardiomyopathy is also included as a manifestation of ICI-related CAEs, but the pathophysiological relevance is unclear. Although the incidence is rare, ICI-related CAEs are life-threatening and potentially fatal. Elucidating pathophysiology and establishing management measures of ICI-related CAEs are one of the most urgent challenges in the field of onco-cardiology.

著者

Koji Mori

出版者

Japan Medical Association / The Japanese Associaiton of Medical Sciences

雑誌

JMA Journal (ISSN:2433328X)

巻号頁・発行日

vol.1, no.1, pp.15-21, 2018-09-28 (Released:2019-10-10)

参考文献数

30

被引用文献数

9

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This paper reviews the circumstances, current situation, and issues for Japanese occupational health physicians and discusses future developments. The Industrial Safety and Health Act requires workplaces that regularly employ 50 or more workers to appoint one occupational health physician. Their duties have been expanded by amendments to the Act, and they now have increased authority. Under these conditions, the occupational health physicians not only comply with laws and regulations but also follow a professional code of ethics. After the Act was amended in 1996, occupational health physicians had to complete additional training requirements. Basic training courses are provided by the Japan Medical Association (JMA) and the University of Occupational and Environmental Health, Japan. Most of the occupational health physicians certified by the JMA do not spend enough time on occupational health. Many Japanese occupational health work issues can be separated into issues of exposure, labor, and the occupational health system. Occupational health is characterized by changing needs because of new industrial structures and technological innovations. Given occupational health physicians' expanding duties and professional development, they need to collaborate with one other and other occupational health staff to meet society's expectations.

著者

Kei Yamamoto Norio Ohmagari

出版者

Japan Medical Association / The Japanese Associaiton of Medical Sciences

雑誌

JMA Journal (ISSN:2433328X)

巻号頁・発行日

vol.4, no.2, pp.67-75, 2021-04-15 (Released:2021-05-07)

参考文献数

50

被引用文献数

8

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Microbiological diagnosis of coronavirus disease 2019 (COVID-19) is mainly performed through nucleic acid amplification test (NAAT) and antigen test. Although NAAT is the standard diagnostic test, its use is limited by insufficient laboratory resources and long turnaround time. Point-of-care NAAT tests have been introduced to address these shortcomings, but their varied sensitivity and resource constraints remain a concern. Antigen tests require fewer resources but have low sensitivity. Nevertheless, low-sensitivity tests may be useful depending on the situation. In contrast, in some clinical phases of COVID-19, high-sensitivity tests may provide false-negative results. Therefore, the right testing strategy is needed for an accurate diagnosis. In this review, the characteristics and clinical applications of microbiological tests available in Japan (NAAT, antigen test, and antibody test) are discussed. The clinical diagnosis of COVID-19 is slightly complicated, and cases in which the infection spreads from asymptomatic infected individuals are many; hence, laboratory diagnosis is essential to prevent further transmission.