- 著者
-
及川 伸二
村田 真理子
平工 雄介
川西 正祐
Shinji Oikawa
Mariko Murata
Yusuke Hiraku
Shosuke Kawanishi
三重大学医学部衛生学教室
三重大学医学部衛生学教室
三重大学医学部衛生学教室
三重大学医学部衛生学教室
Department of Hygiene Mie University School of Medicine
Department of Hygiene Mie University School of Medicine
Department of Hygiene Mie University School of Medicine
Department of Hygiene Mie University School of Medicine
- 出版者
- 日本環境変異原学会
- 雑誌
- 環境変異原研究 = Environmental mutagen research communication (ISSN:09100865)
- 巻号頁・発行日
- vol.23, no.3, pp.207-213, 2001-12-22
- 参考文献数
- 33
Reactive oxygen species are capable of causing damage to various cellular constituents, such as DNA, proteins and lipids, leading to carcinogenesis, aging and a number of diseases. We have investigated the sequence specificity of oxidative stress-mediated DNA damage by using ^<32>P-labeled DNA fragments obtained from the human c-Ha-ras-1, p53 and p16 genes. The sequence specificity of DNA damage plays the key role in the mutagenic process, and affects the mutation frequency. Therefore, investigation on sequence specificity of DNA damage would provide clues on the biological significance of DNA damage which in turn may be beneficial for cancer prevention strategy. Here we discuss the mechanisms and sequence specificity of DNA damage caused by various environmental chemicals and UVA-activated photosensitizers in relation to carcinogenesis and aging.