著者

Shin-ichi NAKAMURA Takamitsu TSUKAHARA

出版者

JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY

雑誌

Journal of Toxicologic Pathology (ISSN:09149198)

巻号頁・発行日

pp.2018-0060, (Released:2019-06-06)

被引用文献数

1

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Herein, we describe the case of a 6-year-old female ferret that died within a few days of the onset of anorexia and reduced spontaneous locomotor activity. Necropsy revealed a dark red abdominal mass of unknown origin between the right lobes of the pancreas and the proximal jejunum, with massive blood retention in the peritoneal cavity. Histopathologically, spindle-shaped or sometimes polygonal tumor cells were proliferating with irregularly shaped vascular spaces containing blood components and surrounding-tissue infiltration. In some areas, tumor cells formed distinctly dilated blood vessel-like structures. Immunohistochemically, most of the tumor cells were strongly positive for CD31, but factor VIII-related antigen immunoreactivity was confined to the area with dilated blood vessel-like structures. Based on these findings, the tumor was diagnosed as an abdominal hemangiosarcoma. Abdominal hemangiosarcoma excluding cases of the liver and spleen are rare in ferrets.

著者

Kazuo Hakoi Taiji Hayashi Kenji Irimura Shuji Hayashi Satoshi Suzuki Shuji Yamaguchi Noboru Konishi Shoji Fukushima

出版者

JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY

雑誌

Journal of Toxicologic Pathology (ISSN:09149198)

巻号頁・発行日

vol.14, no.1, pp.13, 2001 (Released:2001-06-01)

参考文献数

35

被引用文献数

1 1

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DHG, a glycosaminoglycan extracted from the sea cucumber is known to show antithrombotic effects in animals and be a possible therapeutic agent for prevention of disseminated intravascular coagulation. In toxicology study, however, dose-dependent intracellular deposition of eosinophilic or basophilic droplets, and crystalloid substances were observed in the proximal tubular epithelial cells of the kidneys when male Sprague-Dawley rats were administered DHG daily for two weeks at the doses of 10, 100, and 200 mg/kg. In contrast to heparin, a glycosaminoglycan that has been reported to induced similar deposits which were identified to be composed of a hemoglobin-like substance using the alizarin red staining. The inclusions observed in rats given DHG were immunohistochemically positive for α2u-globulin. Moreover, the droplets showed metachromasia in toluidine blue staining, and negative for Hall's, Gmelin's, Schmol's tests, and alizarin red staining, but the crystalloids were positive for alizarin red staining. These results suggested that DHG-induced degeneration of proximal tubular epithelial cells in male rats is related to α2u-globulin accumulation.

著者

伊藤 明弘 後藤 孝彦 藤本 成明

出版者

JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY

雑誌

Journal of toxicologic pathology (ISSN:09149198)

巻号頁・発行日

vol.11, no.2, pp.79-84, 1998-06-01

被引用文献数

2 5

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Cancer is a genetic disease and numerous genetic changes have been disclosed in its developmental stages. Corresponding to those endogenous events, environmental factors including chemicals, oncogenic viruses, and radiation participate in the initiation, promotion, and progression stages. Furthermore, development of cancer is greatly influenced by nutritional factors such as from daily food consumption and the additives in these foods. Retinoids, vitamins, essence of tea, and vegetables are believed to be highly effective in chemoprevention of cancer. In this mini review, miso, a fermented soy product, and the purported active chemopreventative component of soybeans, isoflavones, were examined for their biological activity; 1) during recovery from radiation induced damage, and 2) as a possible chemopreventor of cancers. Thus far, promising results have been obtained for prevention of liver tumors in mice, breast tumors in rats, and intestinal tract tumors in rats. Since chemopreventors derived from natural foods are not cytotoxic, they need not be given to the recipients intermittently. Furthermore, we have found that a combination of tamoxifen with miso greatly reduced occurrence of mammary tumors in rats and therefore might be applicable to human cancers.