著者

奥村 弘 市沢 哲 坂江 渉 佐々木 和子 平川 新 矢田 俊文 今津 勝紀 小林 准士 寺内 浩 足立 裕司 内田 俊秀 久留島 浩 伊藤 明弘 松下 正和 添田 仁 三村 昌司 多仁 照廣

出版者

神戸大学

雑誌

基盤研究(S)

巻号頁・発行日

2009-05-11

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大規模自然災害と地域社会の急激な構造転換の中で、歴史資料は滅失の危機にある。その保存活用を研究する新たな学として地域歴史資料学の構築をめざした。その成果は、第1に、地域住民もまた保存活用の主体と考え地域歴史資料を次世代につなぐ体系的な研究手法を構築しえたことにある。第2は、それを可能とする具体的な地域歴史資料の保存と修復の方法を組み込んだことである。第3は、科研の中間で起こった東日本大震災での地域歴史資料保存について理念と具体的な方法を提示するとともに、全国的な研究者ネットワークによる支援体制を構築したことである。第4は、地域歴史資料学をグローバルイシューとして国際的に発信したことである。

著者

伊藤 明弘 後藤 孝彦 藤本 成明

出版者

JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY

雑誌

Journal of toxicologic pathology (ISSN:09149198)

巻号頁・発行日

vol.11, no.2, pp.79-84, 1998-06-01

被引用文献数

2 5

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Cancer is a genetic disease and numerous genetic changes have been disclosed in its developmental stages. Corresponding to those endogenous events, environmental factors including chemicals, oncogenic viruses, and radiation participate in the initiation, promotion, and progression stages. Furthermore, development of cancer is greatly influenced by nutritional factors such as from daily food consumption and the additives in these foods. Retinoids, vitamins, essence of tea, and vegetables are believed to be highly effective in chemoprevention of cancer. In this mini review, miso, a fermented soy product, and the purported active chemopreventative component of soybeans, isoflavones, were examined for their biological activity; 1) during recovery from radiation induced damage, and 2) as a possible chemopreventor of cancers. Thus far, promising results have been obtained for prevention of liver tumors in mice, breast tumors in rats, and intestinal tract tumors in rats. Since chemopreventors derived from natural foods are not cytotoxic, they need not be given to the recipients intermittently. Furthermore, we have found that a combination of tamoxifen with miso greatly reduced occurrence of mammary tumors in rats and therefore might be applicable to human cancers.

著者

渡辺 敦光 岡本 太郎 山田 和正 安東 保海 伊藤 明弘 星 正治 澤田 昭三

出版者

日本放射線影響学会

雑誌

Journal of Radiation Research (ISSN:04493060)

巻号頁・発行日

vol.34, no.3, pp.235-239, 1993-09

被引用文献数

2 2

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The effects of the dose rate and the energy of fission neutrons using an iron block on tumorigenesis in B6C3F1 mice were examined. Six-week-old female animas were divided into 4 groups and exposes to ^<252>Cf neutron irradiation at dose rates of 0.05 cGy/min, with (Group 1) or without (Group 2) filtering through a 10 cm thick iron block, 0.8 cGy/min (Group 3) or 0 (Group 4 controls). Total neutron exposure was 50 cGy in each of groups 1-3 and total irradiation dose was 56,75 and 75 cGy in Groups 1-3, respectively. Total tumor incidences or multiplicity were significantly higher in Group 3 than in Group 1. A similar tendency was observed as compared to Group 2, ovarian and Harderian gland tumors being mainly affected and adrenal tumors were significantly higher in Group 2 than in Group 1. The results indicated a clear increase in tumorigenesis with the higher dose rate and no filtering influence of iron was evident, despite the drop in neutron energy level.