著者
Chikako TOMIYAMA-MIYAJI Mayumi WATANABE Takahiko OHISHI Yasuhiro KANDA Eisuke KAINUMA Hanaa Y. BAKIR JiWei SHEN HongWei REN Masashi INOUE Keiho TAJIMA XueFeng BAI Toru ABO
出版者
Biomedical Research Press
雑誌
Biomedical Research (ISSN:03886107)
巻号頁・発行日
vol.28, no.3, pp.119-125, 2007 (Released:2007-07-12)
参考文献数
23
被引用文献数
12 14

Since high levels of hyperthermia induce immunosuppression to a certain extent (i.e., granulocytosis and lymphocytopenia) in patients, we applied mild hyperthermia in volunteers using equipment enabling well-controlled hyperthermia. Restricted control of rectal temperature at 39.4 (± 0.2)°C for 30 min was conducted and various parameters of the body were examined. The most prominent change observed during exposure to hyperthermia was elevated levels of pH and PO2 in the blood, even in the venous blood. A transient elevation of ACTH, cortisol and growth hormone in the blood was also seen during this time. In parallel with this phenomenon, the number of total lymphocytes and those of its subsets (especially CD57+ or CD56+ NK cells and NKT cells) increased. More interestingly, the proportion of HLA-DR (MHC class II antigens) increased in NK and NKT cells, and their intensity on the surface of CD20+ B cells increased. These results suggest that mild hyperthermia is important for modulation of the functions of the circulatory, endocrine and immune systems.

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@yonasauna こちらこそありがとうございます! 体温を39℃に上げた研究でも免疫細胞増えたと同じ新潟大学から報告されてます。ドライサウナも同じ結果になりそうな気がします
健康なヒト被験者では、38度の軽度の全身温熱療法でも末梢血NK細胞数が増加した。ただし、局所温熱療法では効果がなかった。 https://t.co/xvPYqhDmd7 39.4℃で30分の全身温熱プロトコルを使用したグループでは、参加者のNK細胞を増加させた。 https://t.co/2pAev212g2
紛うことなきデマ そもそもの根拠論文は加温(健常者)によってNK、NKT、CD8+T細胞が増加したということに過ぎず(https://t.co/KHbdCQDlVS) NK細胞らが増えたからがん細胞減るとかそんな単純な話じゃない https://t.co/TqpDSbwyGH

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