著者

太田 元規 福地 佐斗志 小池 亮太郎

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.57, no.2, pp.085-089, 2017 (Released:2017-03-30)

参考文献数

16

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Protein-protein interactions are fundamental for all biological phenomena. The hub proteins interacting with a number of partner proteins play the vital role in the protein-protein interaction network. We investigated the subcellular localization of proteins in the network, and found that the proteins localized in the multiple subcellular compartments, especially the nucleus and cytoplasm, tend to be hub proteins. Examination on keywords associated with the proteins suggested that those related to post-translational modifications (PTMs) and transcriptions contributed to numerous interactions. Triggered by PTMs in the intrinsically disordered regions, they change interaction partners in the protein complex, and are translocated from cytoplasm to nucleus.