著者
Yasuhiro ITO Hiroshi YOSHIDA Rie MARUO Shinji MORITA Toru TAKANO Mitsuyoshi HIROKAWA Tomonori YABUTA Mitsuhiro FUKUSHIMA Hiroyuki INOUE Chisato TOMODA Minoru KIHARA Takashi URUNO Takuya HIGASHIYAMA Yuuki TAKAMURA Akihiro MIYA Kaoru KOBAYASHI Fumio MATSUZUKA Akira MIYAUCHI
出版者
(社)日本内分泌学会
雑誌
Endocrine Journal (ISSN:09188959)
巻号頁・発行日
vol.56, no.1, pp.89-97, 2009 (Released:2009-03-12)
参考文献数
49
被引用文献数
92 or 0

Recent studies have demonstrated that BRAFV600E mutation is a common event in papillary thyroid carcinoma and a majority of these lesions have shown a direct relationship between BRAFV600E mutation and aggressive characteristics, including a worse patient prognosis. However, there are no studies from Japan regarding this issue in a large series with adequate postoperative follow-up periods. We investigated BRAFV600E mutation in 631 patients with papillary carcinoma having median follow-up periods of 83 months. The prevalence of BRAFV600E mutation was 38.4%, and the rate was higher in carcinoma larger than 1.0 cm but did not successively increase with tumor size. Furthermore, the prevalence did not significantly increase in cases demonstrating high-risk biological features such as clinically apparent lymph node metastasis, massive extrathyroid extension, advanced age, distant metastasis at surgery, and advanced Stage. The disease-free survival of patients with BRAFV600E mutation did not differ from that of those without BRAFV600E mutation. These findings indicate that, although BRAFV600E mutation may play some roles in local carcinoma development, there is no evidence that BRAFV600E mutation significantly reflects the aggressive characteristics and poor prognosis of patients with papillary carcinoma in Japan.

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外部データベース (DOI)

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@YuriHiranuma 2009年、隈病院の論文 https://t.co/WAhajFii1K https://t.co/6afKrLwBMX
最近の日本の成人でのBRAF論文は、隈病院の1996〜2000年の897症例のデータを分析した2009年無料論文で、631例(女性564人、男性67人)中、242例(38.4%)がBRAF陽性。… https://t.co/Kp05SDUlUn
BRAF mutation in papillary thyroid carcinoma in a Japanese population https://t.co/idnZQkTZGn The prevalence of BRAFV600E mutation was 38.4%
ITO Y (2009) "BRAF Mutation in Papillary Thyroid Carcinoma in a Japanese Population: ..." https://t.co/8vhwyJ4knr
この隈病院のデータだと、BRAF mutationは38.4%ですよね。 https://t.co/y5TPrSoufQ 鈴木先生の学会発表のデータは福島健康調査由来のものだけじゃないかもしれないけど、高いってことでしょ。小児だからか放射線関係あるのかは不明だけど。

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