著者
Hisanori Horiuchi Eriko Morishita Tetsumei Urano Kenji Yokoyama the Questionnaire-survey Joint Team on The COVID-19-related thrombosis
出版者
Japan Atherosclerosis Society
雑誌
Journal of Atherosclerosis and Thrombosis (ISSN:13403478)
巻号頁・発行日
vol.28, no.4, pp.406-416, 2021-04-01 (Released:2021-04-01)
参考文献数
15

A questionnaire on COVID-19-related thrombosis in patients hospitalized before Aug 31, 2020, was sent to 399 hospitals throughout Japan. Responses were received from 111 (27.8%) with information on 6,202 COVID-19 patients. Of these, 333 and 56 required ventilation or extracorporeal membrane oxygenation (ECMO), respectively, and 212 died (3.4%). D-dimer levels were measured in 75.0% of the patients, revealing that 9.2% and 7.6% exhibited D-dimer increases of 3-8-fold and ≥8-fold the reference value, respectively. Thrombotic events occurred in 108 patients (1.86% of the 5,807 patients with available data) including symptomatic cerebral infarction in 24, myocardial infarction in 7, deep vein thrombosis in 41, pulmonary thromboembolism in 30, and other thrombotic events in 22. Some patients developed multiple thrombotic events. Thrombosis occurred in 32 patients with mild or moderate COVID-19 severity (0.59% of those with data available) and in 52 patients on ventilation or ECMO (13.5% of severe patients for whom data were available). Thrombosis occurred in 67 patients during worsening clinical condition and in 26 during recovery. Anticoagulant therapy was provided to 893 patients (14.6% of the 6,119 patients with available data), the main reasons being provided as elevated D-dimer levels and worsening clinical condition.

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外部データベース (DOI)

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COVID-19-Related Thrombosis in Japan: Final Report of a Questionnaire-Based Survey in 2020 https://t.co/MiwHWatgmN 日本におけるCOVID-19関連血栓症:2020年のアンケートベースの調査の最終報告
(1)血栓症は、COVID-19入院患者の1.86%に発症し、軽症・中等症患者では0.59%と低い発症率。重症COVID-19患者では13.5%と高い発症率。 (2)D-ダイマーは頻繁に測定され(75.0%の患者からデータが返却された)、3-8倍、8倍以上の増加を示した患者はそれぞれ9.2%、7.6% https://t.co/5VIHSWkzEs

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