著者
Noriko KOBAYASHI
出版者
Japan Health Physics Society
雑誌
保健物理 (ISSN:03676110)
巻号頁・発行日
vol.54, no.1, pp.55-65, 2019-04-18 (Released:2019-09-03)
参考文献数
20

The International Commission on Radiological Protection (ICRP) internal dose assessment model, currently adopted in Japanese regulation, assumes uniform distribution of radionuclides in bone marrow blood (ICRP Publication 60). Recent studies have revealed a localization of hematopoietic stem cells (HSCs) and immune cells in the perivascular region of the bone marrow sinusoids, suggesting a need to consider nonuniform distributions of the blood source and HSCs. To evaluate energy transfer to HSCs, a simplified model of cervical vertebrae with bone tissues and blood vessels was built using data from the adult Japanese male phantom. Doses absorbed by HSCs from blood and hard bone sources were calculated using a Monte Carlo simulation, and absorbed fractions (AFs) and specific absorbed fractions (SAFs) from electrons were compared with those in the ICRP 1990 model. In the cervical vascular model, electron SAFs from sinusoidal blood in the red bone marrow (RBM) to the target perivascular region were 1.2 to 6.9 times higher than the SAF in the ICRP 1990 model, suggesting an underestimation of the RBM dose. Electrons from the cortical bone source to the perisinusoidal target exhibited energy transfer. The ICRP 1990 model underestimates electron SAFs from radionuclides in sinusoidal blood and cortical bones. A more elaborate model is needed to examine doses for the RBM and effects on hematopoietic and immune functions.

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@higuma_saikyou パトさん論文書きましたね。これ。 https://t.co/nXHYmdIXVq
「ぱとり仮説」が論文になりました。 Evaluation of Doses Absorbed to a Bone Marrow Stem Cell Layer from Short-lived Radionuclides in the Blood Vessels and from Long-lived Radionuclides in the Cortical Bone https://t.co/o4f0YG6Akt  ICRP内部被曝モデルを検証する内容です。
保健物理 英語論文) Evaluation of Doses Absorbed to a Bone Marrow Stem Cell Layer from Short-lived Radionuclides in the Blood Vessels and from Long-lived Radionuclides in the Cortical Bone https://t.co/oPSzfK4WHq

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