著者
仲安 義行
出版者
日本薬史学会
雑誌
薬史学雑誌 (ISSN:02852314)
巻号頁・発行日
vol.55, no.1, pp.13-20, 2020 (Released:2020-08-02)

Ursodeoxycholic acid (UDCA) is a bile acid used worldwide for improving hepatic, bile, and digestive functions. UDCA was first introduced to the world more than 60 years ago as URSOR Powder in Japan by Tokyo Tanabe Pharma Co., Ltd. (founded in 1901 by Motosaburo Tanabe). However, the origin of this medicine is even older; that is, it was an animal crude drug called “YUTAN” made from bear gallbladder. The same as other western medicines, chemical synthesis was necessary to commercialize UDCA. It was an exceptionally rare agent that required isolation, crystallization, determination of structural formula, and establishment of an efficient synthetic method all conducted by Japanese researchers. After being commercialized, URSO was approved for additional indications of gallstone dissolution (1978), implementation of liver function in primary biliary cirrhosis (1999), and chronic hepatitis C (2007). These achievements were the result of the unflagging efforts of many researchers. Although 60 years have passed after the market launch, UDCA sales are still growing globally and high-quality bulk powder is continuously supplied from Japan to the world. This article discusses the development history of URSO in view of the relationship with the brief history of Mitsubishi Tanabe Pharma Corporation.

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肝臓がアレな子なのでウルソデオキシコール酸を毎食飲んでいるのですが、これは熊の胆の有効成分らしく、昔だったら貴族しか飲めないような薬を気軽に飲める現代って凄いなぁと思ってます。
現在も世界各国で肝疾患などに広く用いられているウルソデオキシコール酸(UDCA)が世界で初めて発売されたのは,今から 60 年以上も前の日本においてであった 【薬史学雑誌 55(1) p13-20, 2020】 日本生まれの肝 ・ 胆 ・ 消化機能改善剤 ウルソデオキシコール酸開発の歩み https://t.co/4ptpV7mxIb

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