著者

田丸 淳一 高橋 直樹 磯部 公一 糸山 進次

出版者

The Japanese Society for Lymphoreticular Tissue Research

雑誌

日本リンパ網内系学会会誌 (ISSN:13429248)

巻号頁・発行日

vol.39, no.5-6, pp.259-263, 2000-02-15 (Released:2009-10-30)

参考文献数

17

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Antibody molecules produced by B cells are engaged in the humoral immunity. Antibodies have molecular diversity to respond specifically to each of innumerable species of antigen. Antibody molecular diversity is the immediate result of immunoglobulin gene diversity which is formed by complicated processes including VDJ rearrangement and is thought to reflect differentiation status of B cells. Somatic mutation occurs in these immunoglobulin genes after main VDJ rearrangement and also plays an important role in further widening of molecular diversity.In recent years, the significance of somatic mutation of immunoglobulin gene in B-cell differentiation process was made clear, and as the result, identification of the normal counterpart of tumor cells became possible on gene level studies, which had been judged mainly from histocytological and immunohistochemical studies.