著者

田丸 淳一 高橋 直樹 磯部 公一 糸山 進次

出版者

The Japanese Society for Lymphoreticular Tissue Research

雑誌

日本リンパ網内系学会会誌 (ISSN:13429248)

巻号頁・発行日

vol.39, no.5-6, pp.259-263, 2000-02-15 (Released:2009-10-30)

参考文献数

17

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Antibody molecules produced by B cells are engaged in the humoral immunity. Antibodies have molecular diversity to respond specifically to each of innumerable species of antigen. Antibody molecular diversity is the immediate result of immunoglobulin gene diversity which is formed by complicated processes including VDJ rearrangement and is thought to reflect differentiation status of B cells. Somatic mutation occurs in these immunoglobulin genes after main VDJ rearrangement and also plays an important role in further widening of molecular diversity.In recent years, the significance of somatic mutation of immunoglobulin gene in B-cell differentiation process was made clear, and as the result, identification of the normal counterpart of tumor cells became possible on gene level studies, which had been judged mainly from histocytological and immunohistochemical studies.

著者

児玉 龍彦

出版者

The Japanese Society for Lymphoreticular Tissue Research

雑誌

日本リンパ網内系学会会誌 (ISSN:13429248)

巻号頁・発行日

vol.38, no.5-6, pp.261-269, 1999-01-30 (Released:2009-10-30)

参考文献数

39

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A hallmark of atherosclerosis is the deposition of plasma cholesterol in atherosclerotic plaques in arterial walls. Key cellular components of atherosclerotic plaques are foam cells, which are derived from monocytes-macrophages. In order to elucidate the molecular mechanism of foam cell formation, we cloned and characterized cDNA for type I and II MSR. Type I and II MSR can bind an extraordinary wide range of ligands using its “charged collagen structure”, including modified low density lipoproteins (mLDL) and bacterial pathogens. MSR also mediates phagocytosis of apoptotic cells and cation-independent macrophage adhesion in vitro. Targeted disruption of type I and II MSR gene in mice results in a marked reduction in the size of atherosclerotic lesions in an animal deficient in apolipoprotein E. Macrophages from type I and II MSR deficient mice show a marked decrease in mLDL degradation activity in vitro, whereas mLDL clearance from the plasma occurs at a normal rate. In addition, type I and II MSR-knockout mice show an increased susceptibility to infection with Listeria monocytogenes or herpes simplex virus type I, indicating that type I and II MSR may play a part in host defense against pathogens.

著者

切替 照雄 新田 敏正 中野 昌康

出版者

The Japanese Society for Lymphoreticular Tissue Research

雑誌

日本リンパ網内系学会会誌 (ISSN:13429248)

巻号頁・発行日

vol.38, no.1, pp.11-27, 1998-04-20 (Released:2009-06-04)

参考文献数

97

著者

児玉 龍彦

雑誌

日本リンパ網内系学会会誌 = The journal of the Japanese Society of Lymphoreticular Tissue (ISSN:13429248)

巻号頁・発行日

vol.38, no.2, 1998-04-20