著者
Tomomi TAKANO Chisako KAWAKAMI Shinji YAMADA Ryoichi SATOH Tsutomu HOHDATSU
出版者
JAPANESE SOCIETY OF VETERINARY SCIENCE
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
vol.70, no.12, pp.1315-1321, 2008 (Released:2009-01-01)
参考文献数
27
被引用文献数
40 44

Feline infectious peritonitis virus (FIPV) is classified into serotype I and serotype II according to the amino acid sequence of its spike(S) protein. Antibody dependent enhancement (ADE) of macrophage infection occurs in the presence of antibodies to FIPV S protein, and a close relationship between ADE and neutralizing epitopes has been reported. The importance of differences in FIPV serotype on the induction of ADE remains unclear. In this study, we investigated whether the same or different serotype of FIPV induces ADE in cats. Specific pathogen-free cats were passively immunized with anti-type I or II FIPV antibodies, and we investigated the induction of ADE following subcutaneous inoculation with type I FIPV. Inoculation using FIPV serotype I enhanced the onset of FIP in cats passively immunized with FIPV serotype I-specific antibodies but not in those passively immunized with antibodies to FIPV serotype II. These data suggest that re-infection with the same serotype induces ADE in cats infected with FIPV.

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@RaoulGMI @capitalistexp @LibertyBlitz @DavidBCollum "The ADE of FIPV infection is a barrier to the development of FIPV vaccines" https://t.co/3sXyJYT2oD Best we skip the pesky animal studies & go straight to planetary scale human injections. I mean, what could possibly go wrong? Extinction events are cool.
@rvh15374957 @Saskia_Furdytje @TharusThijs ADE bij coronavirussen: fretten in vivo. https://t.co/3f2s95jkm8 katten in vivo https://t.co/jF0YUIleUR SARS in vitro https://t.co/OtJO2RdZAP SARS in vivo (muis) https://t.co/uhq2J7zffw
SARS-CoV-2 potential for antibody dependent enhancement (ADE) is an open question. In Feline Infectious Peritonitis Virus, enhancement can occur due to reinfection by an identical serotype. Reinfection by SARS-CoV-2 could be a factor @jbloom_lab @RELenski https://t.co/G9RdhYRcyT https://t.co/YtYndWCiGN

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