著者

中村 成夫

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.9, no.1, pp.25-30, 2013 (Released:2013-03-11)

参考文献数

7

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Drug metabolism involves chemical reactions modifying pharmaceutical substances. Lipophilic chemical compounds are converted to hydrophilic compounds by enzymes related to drug metabolism. Some drugs are activated after drug metabolism; on the other hand, some xenobiotic compounds become toxic through these enzymes. Cytochrome P450 is an enzyme that plays a major role in drug metabolism. Metabolites produced by cytochrome P450 from one drug are predictable from the viewpoint of chemical reactivity. Novel metabolites from nonylphenol and bisphenol A are discovered considering the ipso-position metabolic reaction of cytochrome P450.