著者

室井 一男

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.11, no.4, pp.197-200, 2015-10-15 (Released:2015-11-26)

参考文献数

3

著者

小金沢 滋

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.35, no.1, pp.50-61, 1968-02-15 (Released:2010-10-14)

参考文献数

345

著者

中村 成夫

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.9, no.3, pp.164-169, 2013 (Released:2013-07-08)

参考文献数

7

被引用文献数

2 2

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Reactive oxygen species (ROS) are produced from molecular oxygen. ROS are the reduced forms of molecular oxygen and have high reactivity to biological components e.g. lipid, protein, and nucleic acid. ROS are considered to cause various diseases e.g. arteriosclerosis, myocardial infarction, cancer, and so on. A living body protects against ROS by antioxidant enzymes e.g. superoxide dismutase (SOD) and catalase. Natural antioxidants e.g. ascorbic acid (vitamin C) and α-tocopherol (vitamin E) also scavenge ROS. Recently, some novel artificial antioxidants are synthesized and are expected to a lead compound for drugs.

著者

白倉 毅

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.27, no.5, pp.792-814_2, 1960-05-15 (Released:2010-10-14)

参考文献数

26

著者

伊藤 保彦 五十嵐 徹 立麻 典子 今井 大洋 吉田 順子 土屋 正己 村上 睦美 福永 慶隆

出版者

日本医科大学医学会

雑誌

Journal of Nippon Medical School (ISSN:13454676)

巻号頁・発行日

vol.66, no.4, pp.239-244, 1999-08-15 (Released:2000-04-12)

参考文献数

27

被引用文献数

1 1

---

We have encounted two patients with fibromyalgia (FM) initially diagnosed as having autoimmune fatigue syndrome (AIFS). To investigate the relationship between AIFS and FM, the distribution of the tender points in patients with AIFS was assessed according to the ACR criteria for FM. It was revealed that AIFS patients had 5.6 tender points on averages. Patients with headaches, digestive problems, or difficulty going to school had more tender points than patients without. Patients with ANA titers

著者

山本 馨 栗原 毅 福生 吉裕

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.8, no.2, pp.179-180, 2012 (Released:2012-05-30)

参考文献数

6

被引用文献数

2 5

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Anisakiasis is a disease characterized by the abrupt onset of sharp epigastric pain, typically a few hours after eating raw or undercooked seafood. At present, the most common effective treatment is endoscopic removal. However, over 23 years Yamamoto has used an antiallergic drug (Stronger Neo-Minophagen C) and prednisolone to treat more than 190 patients with anisakiasis diagnosed on the basis of symptoms and without endoscopy. In this report, Kurihara reconfirms the effectiveness of this unique treatment for patients with endoscopically diagnosed anisakiasis. On the basis of these findings, we propose that the combination therapy of an antiallergic drug and a corticosteroid is a reasonable, inexpensive, and safe method for treating anisakiasis.

著者

鈴木 俊治

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.11, no.2, pp.102-104, 2015-04-15 (Released:2015-05-26)

参考文献数

12

---

We surveyed seven teenagers who gave birth without visiting antenatal clinics. Although six of the seven had been aware that they were pregnant, they had not felt able to talk with their parents about their pregnancies.

著者

清水 一雄 佐藤 英尊 汲田 伸一郎

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.7, no.3, pp.135-137, 2011 (Released:2011-07-06)

著者

高橋 秀実

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.13, no.3, pp.140-144, 2017-06-15 (Released:2017-07-20)

参考文献数

6

著者

北川 亘 清水 一雄 赤須 東樹 田中 茂夫

出版者

日本医科大学医学会

雑誌

Journal of Nippon Medical School (ISSN:13454676)

巻号頁・発行日

vol.70, no.1, pp.57-61, 2003 (Released:2003-02-24)

参考文献数

11

被引用文献数

9 12

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Thyroid disease is comparatively prevalent, and it is important to perform careful palpation of the anterior neck when patients are first examined. In this paper, the latest data on and clinical characteristics of the epidemiology of thyroid carcinoma are described.According to Japanese cancer statistics, in 1996, the number of cases of thyroid carcinoma was 1,390 men and 5,437 women. The female to male ratio was 3.91: 1. The crude rate of thyroid carcinoma per 100,000 population was 2.3 men and 8.5 women. The age-adjusted incidence rate showed a gradual increase with age, and the peak of the age-adjusted incidence rate was over 80 years old among men, and from 70 to 80 years old among women.According to the Japanese Thyroid Cancer Registration Committee, from 1977 to 1999, papillary thyroid carcinoma accounted for more than 85% (30,256) of thyroid carcinomas among 35,312 patients. Medullary thyroid carcinoma (1.4%) and anaplastic thyroid carcinoma (1.6%) were rare. The female to male ratio of thyroid carcinoma was 6.1: 1. Registration was made in accordance with the general rules issued by the Japanese Society of Thyroid Surgery. According to the vital statistics, mortality related to thyroid carcinoma among all cancer-related deaths was 0.23% among men (411) and 0.76% among women (887) in 2000. The female to male ratio of mortality was 2.16: 1. The peak of mortality was from 70 to 80 years old among men, and from 80 to 90 years old among women.Most patients with differentiated thyroid carcinoma had a low mortality rate, but anaplastic carcinoma had a poor prognosis. Lung and bone were the main distant metastatic sites, and respiratory insufficiency was the most common specific fatal condition.

著者

丸山 千里

出版者

日本医科大学医学会

雑誌

日本医科大学雑誌 (ISSN:00480444)

巻号頁・発行日

vol.38, no.5, pp.267-276_26, 1971 (Released:2010-12-22)

参考文献数

25

被引用文献数

4 5

著者

坂本 篤裕

出版者

日本医科大学医学会

雑誌

Journal of Nippon Medical School (ISSN:13454676)

巻号頁・発行日

vol.70, no.1, pp.66-68, 2003 (Released:2003-02-24)

参考文献数

5

被引用文献数

2 2

---

Erythromelalgia is a rare condition that is characterized by the triad of redness, increased temperature, and intense pain of feet or hands. This syndrome was first described in 1878, however, universal classification, precise mechanism and successful medical treatment of erythoromelalgia have not been described. We experienced 3 cases of erythomelalgia in our outpatient pain clinic that showed the different progress. One patient experienced the long-term pain complicated with neuropathic pain. The pain of other two patients was eliminated early by nerve block treatments, and they did not showed chronic pain. From the prophylactic viewpoint of chronic pain, the most considerable matter is early and certain elimination of severe pain under certain diagnosis. In this article, the mechanisms of passing into the chronic pain state as well as the efficacy of neural blockade for intractable pain such as erythromelalgia are discussed.

著者

小澤 一史

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.4, no.1, pp.25-31, 2008 (Released:2008-03-17)

参考文献数

20

被引用文献数

1 1

---

The neuroendocrine system of the hypothalamus is involved with the regulation of pituitary hormone secretion and with feeding, sexual behavior, stress response, and circadian rhythm. The neuronal networks for the regulation of feeding, sexual behavior, and stress responses communicate with and influence each other in a complex manner. This paper presents an overview of the interaction of these neuroendocrine systems, particularly from of the point of view of the mechanism of the onset of puberty.

著者

Hidehisa Saeki

出版者

日本医科大学医学会

雑誌

Journal of Nippon Medical School (ISSN:13454676)

巻号頁・発行日

vol.84, no.1, pp.2-11, 2017-01-15 (Released:2017-03-22)

参考文献数

37

被引用文献数

15

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The guidelines for the treatment of atopic dermatitis (AD) issued by the Japanese Dermatological Association (JDA), which are basically designed for dermatologists, were first prepared in 2000 and revised in 2016. The guidelines for AD of the Japanese Society of Allergology (JSA), which are basically designed for allergologists, including internists, otorhinolaryngologists, ophthalmologists, and dermatologists, were first prepared in 2009 and revised in 2014. In this article, I review the definition, pathophysiology, etiology, epidemiology, diagnosis, severity classification, examination for diagnosis and severity assessment, and treatments for AD in Japan according to these two guidelines for AD (JDA and JSA). Based on the definition and diagnostic criteria for AD of the JDA, patients meeting three basic criteria, 1) pruritus, 2) typical morphology and distribution of the eczema, and 3) chronic or chronically relapsing course, are regarded as having AD. Treatment measures for AD basically consist of drug therapy, skin care, and elimination of exacerbating factors. Drugs that potently reduce AD-related inflammation in the skin are topical corticosteroids and tacrolimus. It is most important to promptly and accurately reduce inflammation related to AD by using these topical anti-inflammatory drugs. Proactive therapy refers to a treatment method in which, after inducing remission, a topical corticosteroid or tacrolimus ointment is intermittently applied to the skin in addition to skin care with moisturizers in order to maintain remission.

著者

江上 格

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.13, no.1, pp.4-5, 2017-02-15 (Released:2017-03-07)

著者

山内 栄五郎 熊野 玲子 小林 憲 服部 貴行 松本 純一 大西 毅 早川 美奈子 谷 一朗

出版者

日本医科大学医学会

雑誌

Journal of Nippon Medical School (ISSN:13454676)

巻号頁・発行日

vol.69, no.5, pp.471-475, 2002 (Released:2002-10-25)

参考文献数

16

被引用文献数

22 19

著者

松崎 利行

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.5, no.2, pp.118-124, 2009 (Released:2009-05-15)

参考文献数

25

被引用文献数

1 1

---

Aquaporins are membrane water channel proteins through which water permeates the lipid bilayer. So far 13 aquaporin isoforms, aquaporin-0 (AQP0) to AQP12, have been identified in mammals. They are classified into 3 subgroups: 1) aquaporins that selectively transfer water, 2) aquaglyceroporins that transfer some small solutes as well as water, and 3) unorthodox aquaporins. They are widely distributed in most water-handling organs, such as kidney, and play important roles in water transfer. For example, segment-specific expression of AQP1, AQP2, AQP3, AQP4, AQP6, AQP7, and AQP11 in the renal tubular epithelium enables water reabsorption to produce concentrated urine. Aquaporins are usually localized to the plasma membrane. Some isoforms, such as AQP2, are present in the intracellular membrane compartment. AQP2 in collecting duct cells translocates between intracellular vesicles and the cell surface via a membrane trafficking mechanism. Mutations of AQP2 result in congenital nephrogenic diabetes insipidus. This review summarizes the distribution and physiological importance of aquaporins, with a special focus on the kidney.

著者

茨木 信博

出版者

日本医科大学医学会

雑誌

Journal of Nippon Medical School (ISSN:13454676)

巻号頁・発行日

vol.69, no.4, pp.404-405, 2002 (Released:2002-08-23)

参考文献数

10

著者

東 直行 狩野 律子

出版者

日本医科大学医学会

雑誌

日本医科大学医学会雑誌 (ISSN:13498975)

巻号頁・発行日

vol.4, no.4, pp.205-209, 2008 (Released:2009-01-15)

参考文献数

5

被引用文献数

2

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Drug-induced hypersensitivity syndrome (DIHS) is a rare but severe disease associated with multiorgan failure. The association of DIHS with human herpes virus 6 (HHV-6) has recently been reported. We report on an 89-year-old woman with allopurinol-induced DIHS diagnosed on the basis of symptoms and laboratory examinations. A rash appeared as erythema on the trunk and extremities and edematous erythema on the face. Renal dysfunction, leukocytosis, eosinophilia, and atypical lymphocytes were also present. An elevated titer of antibodies against HHV-6 and HHV-6 DNA in the blood were observed during the course of the disease (1 : 20 to 1 : 1280). Discontinuation of allopurinol administration and systemic corticosteroid treatment led to an improvement, but symptoms worsened when the corticosteroid dosage was tapered. An elevated titer of antibodies against cytomegalovirus was detected during the course of the disease. The patient died of pneumonia, most likely related to cytomegalovirus. This case indicates that, in addition to the reactivation of HHV-6, reactivation of cytomegalovirus may modify clinical disease activity.

著者

Tsutomu Igarashi Yuri Nakazato Tomoyuki Kunishige Miho Fujita Yumi Yamada Chiaki Fujimoto Kimihiro Okubo Hiroshi Takahashi

出版者

日本医科大学医学会

雑誌

Journal of Nippon Medical School (ISSN:13454676)

巻号頁・発行日

vol.79, no.3, pp.182-189, 2012 (Released:2012-07-05)

参考文献数

24

被引用文献数

1 7

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Background: Recent studies have examined the effects of intranasal corticosteroids (INSs) in relieving the ocular symptoms of seasonal allergic rhinoconjunctivitis (SAR) and perennial allergic rhinitis. However, because most of these studies were based on subjective assessments by patients, the associated factors and mechanism of action are unknown. Methods: A single-center, randomized, double-blind, parallel-group study was carried out in which patients with SAR were randomly assigned to an INS mometasone furoate nasal spray (MFNS) group or to a placebo group and treated once daily for 4 weeks. Substance P concentrations in tears were measured, ocular and nasal symptoms were recorded by patients in an allergy diary, and findings were recorded by an ophthalmologist. Results: There was no significant difference between treatment groups in the mean change from baseline of substance P concentration in tears after 4 weeks of treatment, but the mean change tended to increase in the placebo group and tended to decrease in the MFNS group (P = 0.089). All ocular and nasal symptom scores, except eye tearing, were significantly lower in the MFNS group than in the placebo group. Furthermore, substance P concentrations were strongly correlated with ocular and nasal symptom scores. Conclusions: In patients with SAR, INSs tend to decrease the substance P concentration in tears, which is correlated with the severity of ocular and nasal symptoms.