著者

工藤 卓 田口 隆久

出版者

公益社団法人 計測自動制御学会

雑誌

計測自動制御学会論文集 (ISSN:04534654)

巻号頁・発行日

vol.42, no.4, pp.351-358, 2006-04-30 (Released:2009-03-27)

参考文献数

11

被引用文献数

3 3

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The spatiotemporal patterns of spontaneous action potential were analyzed, using the multi-site recording system for extracellular potentials of neurons and the living neuronal network cultured on a 2-dimensional electrode array. The map of functional connections between neurons revealed that each culture contained some hub-like neurons, and the connections were drastically re-organized by continuous feedback stimulation. These results strongly suggest that the network structure of the cultured hippocampal neurons is neither stable nor random, but is functionally dynamic and tunable in order to be suitable for certain types of information processing. So we proposed a hypothesis; the interaction to environment generate the specific rules in the spatiotemporal pattern of nerve electrical activities. Our goal is reconstruction of the neural network, which can process “thinking.” in the dissociated culture system.