- 著者
-
福井 裕行
- 出版者
- 公益社団法人 日本薬学会
- 雑誌
- YAKUGAKU ZASSHI (ISSN:00316903)
- 巻号頁・発行日
- vol.127, no.1, pp.15-25, 2007-01-01 (Released:2007-01-01)
- 参考文献数
- 18
- 被引用文献数
-
1
1
Histamine H1 receptors are down-regulated as one step in receptor desensitization. Five phosphorylation sites of the H1 receptor seem to play a key role in receptor down-regulation. In contrast, an increase in the H1 receptor expression level following its mRNA elevation was found in the nasal mucosa in hypersensitivity model rats. Up-regulation of the H1 receptor was induced by the direct stimulation of the H1 receptor. H1 receptor up-regulation was suppressed by pretreatment with antiallergic agents.