著者

安本 三治 山下 純一 橋本 貞夫

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.98, no.11, pp.1551-1553, 1978-11-25 (Released:2008-05-30)

参考文献数

10

被引用文献数

6 5

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Synthesis of 3-(tetrahydro-2-furanyl)-5-fluorouracil (3-Thf-FU) (III), which has been found to be a metabolic intermediate of 1, 3-bis (tetrahydro-2-furanyl)-5-fluorouracil (Thf2-FU) and an effective antitumor agent, is reported. 1-Alkane- or 1-arene-sulfonyl-5-fluorouracil (I) was trimethylsilylated by treatment with N, O-bis (trimethylsilyl) acetamide and treated with 2-acetoxytetrahydrofuran in the presence of stannic chloride to give 1-alkane- or 1-arene-sulfonyl-3-(tetrahydro-2-furanyl)-5-fluorouracil (II). III was obtained by deblocking of II with methanolic ammonia.