著者

新井 和孝

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.44, no.6, pp.486-498, 1986-06-01 (Released:2010-01-22)

参考文献数

52

被引用文献数

4 8

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In recent years, synthetic method by the combination of isomerization and crystallization is studied intensively, especially in the practical optical resolution. In this paper, this isomerization-crystallization method is introduced from a point of view of practical organic synthesis. A number of examples of this isomerization-crystallization method in optical resolution, many of which were often reported as the example of second-order asymmetric transformation phenomena, are classified into following two groups, and reviewed.(1) Epimerization-crystallization method.(2) Racemization-preferential crystallization method.The potentialities and difficulities of each method are also discussed. The compounds resolved by this methods are α-amino acid derivatives, cyanohydrin derivatives, α-aromatic carboxylic acid esters, and so on.