著者

前田 満和

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.49, no.11, pp.1021-1031, 1991-11-01 (Released:2009-11-16)

参考文献数

54

被引用文献数

1 3

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Cisplatin [cis-dichlorodiammineplatinum (II)] has been widely used for clinical cancer chemotherapy though the complex has severe side effect such as renal toxicity. This article is summarized synthetic method, reactivities, and mechanism of action against target molecules of cisplatin. And a part of newly synthesized cisplatin analogs including our liposoluble or water miscible platinum (II) complexes are summarized with their antitumor activities against experimental tumors.