@Jos21Bell @NeurologistMom Being careful that just because you don't think non-covid ME does not do something doesn't mean it doesn't. 'non-covid ME doesn't have cardiac issues'. I got new-onset arrythmia severe enough to put me in hospital age 10 coincident with ME onset in 1983. https://t.co/V61Fp4ayKb
@mommyflommie @gardenbev @EricTopol To a degree I question this as there has been too little research. The little that has been done finds neglected problems. (one of many areas) There is likely a particular effect of covid that leads to significant mortality in the first year. https://t.co/V61Fp4b6zJ
@wendydheard Went to a cardiologist (1984) with new-onset sinus bradycardia, and the response was pretty much 'huh, you don't seem at risk of death, goodbye'. (onset along with a matching set of symptoms to #LC) There isn't an understanding of this mechanism or treat. https://t.co/V61Fp3SXlB
@DocBorelli @EricTopol @NatureMedicine @v_puntmann @GoetheCVI I note https://t.co/V61Fp4ayKb - I wonder how much of this surprise is due to simply not looking in various post acute infectious syndromes.
@Dakota_150 'As it turned out, the 28-year-old’s heart had shrunk, both visually and in performance. Kriegerstein’s cardiac output as a top athlete of more than 90 percent declined to 60 percent. The normal value is about 70 percent.' https://t.co/V61Fp4ayKb
@BinitaKane Reminded of sudden onset sinuous arythmia age 10, post 'mild' viral infection leading to something like #longcovid these past 40 years. Also recalling. We know too little about 'normal' post viral. https://t.co/V61Fp4ayKb
@EricTopol @NatureMedicine @zalaly @WUSTLmed Thinking of my new onset Sinus Tachycardia at 10, forty years ago, coincident with the onset of long-something. (probably EBV). I note also https://t.co/V61Fp4ayKb
@SGriffin_Lab Whoops. https://t.co/V61Fp4ayKb was the intended link. (the first is tangentially related only in that updosed loratadine seems to help me, and the above speaks to its safety and that updosing is recommended to be effective in some other conditions)
@winstoncrowder @edyong209 One option of the reactivation hypothesis is that any 'significant' stress can cause it. It would be rather odd if C19 was completely unique. I note https://t.co/V61Fp3SXlB for example, in prior post-viral conditions. Having said this, the live virus is a much more severe insult.
@doctorasadkhan @EleanorDavin https://t.co/V61Fp4ayKb I note. the amount of active research done is _TINY_. I developed severe sinuous arhythmia at 10yo post virally as one of the spectrum of #mecfs symptoms. There clearly are LC symptoms that don't occur in #mecfs . And there is a large group of LC
that are not normal symptoms of exercise. (cognitive, speech, pain, sleep problems, ...) in the days following exercise. Not doing so may cause progressive lifelong worsening of #longcovid to the point you are unable to do most things. https://t.co/V61Fp4ayKb
@AngryCardio @CoyneoftheRealm https://t.co/V61Fp4ayKb I note. I found no mention of correlation between heart symptoms and any longcovid issues further from diagnosis.
@amibanerjee1 @trishgreenhalgh @PerspectumGroup @LongCovidSOS @Dr2NisreenAlwan @profhelenward I note https://t.co/V61Fp4ayKb that cardiac abnormalities are found in more than half of CFS patients. I would love to see a control group be CFS patients with onset ~Aug-Dec 2019 compared with C19 ~Feb-Mar. and C19 Nov-Dec.This (or gold standard NZ CFS) would allow chronological
@stephenlutz @TomKindlon Indeed. https://t.co/V61Fp4ayKb I'd quite like followup on this for example. Cardiac abnormalities found on careful exam of >60% of patients with CFS.
@RobinGorna @TheLancet We are early to say the fatigue course of #mecfs and #longcovid are driven or are not driven by the same pathology. There are obviously different symptoms post covid, but at least a subset of what are thought to be 'covid only' may be due to lack of work. https://t.co/V61Fp4ayKb
@WhatNewsScience @marydimmock @Dan_Wyke 'look at the heart' I note https://t.co/V61Fp4ayKb . I don't believe the science is there to say it is/is not #mecfs triggered by covid plus prompt covid effects. (which is my belief)
@Azeem_Majeed @trishgreenhalgh This is not due to simple cardiac issues or lung capacity, or any coagulopathy effects. https://t.co/V61Fp4ayKb We do not know if longcovid is covid toes+post-severe heart/lung manifestations+#MECFS for the fatigue and other symptoms. If it is, extreme exercise caution is vital.
@ohhjacqui @jakesuett @bmj_latest Calling them false negative cases assumes covid is the only cause. We do not know this. https://t.co/V61Fp4ayKb I note. I developed a disease with symptoms matching #longcovid after a trivial virus 1990. Around 1000 in the UK/3mo get #mecfs and will be mixed in with #longcovid.
@dysclinic Cardiac issues are quite common in #mecfs https://t.co/V61Fp4ayKb for one. It would be interesting to do detailed cardiac workups on #mecfs patients with non-covid onset and covid #longcovid patients.
@CardioOncology @NakedCapsid @davidrliu https://t.co/V61Fp4ayKb I note, along with CFS symptoms being similar to #longcovid . (30 years out from presumed viral infection triggering CFS and cardiac arrythmia)
@MBVanElzakker https://t.co/V61Fp4ayKb I sit here with sinus arrythmia and irregular heartbeat symptoms that occured at age 12 post a 'trivial'l virus that triggered/caused ME/CFS. My view is longcovid is likely symptoms specific to covid + triggered CFS state.
@trishgreenhalgh https://t.co/V61Fp4ayKb Is one of the papers showing heart issues in #mecfs. 'Echocardiographic examination demonstrated low cardiac indexes (<2 L/min/m2) with low stroke volume indexes (<30 mL/m2) due to a small left ventricular chamber in 19 (36%, p<0.05 vs. 8% in 36 controls)
@benjamesmorton @ISARIC1 @louise_sigfrid @UofGlasgow @JTSglobalhealth @WHO @fernando_bozza @gail_carson If you are picking up #longcovid symptoms after nonspecific viral illness, you are going to find some of those 400/day. https://t.co/V61Fp4ayKb #mecfs has a wide variety of symptoms. Answering if it's coincident or directly caused requires a SARS2 test or diagnosis.
@TomKindlon @mhornig @davidtuller1 I wonder if some of these cases are 'background' CFS/ME developing being assumed to be covid, as 'it can't be CFS/ME as that's trivial and just tiredness'. (developed tachycardia/MECFS after a trivial virus infection in 198?) https://t.co/V61Fp4ayKb several cardiac papers
@fascinatorfun covid - it doesn't seem unreasonable that it might trigger it too. #mecfs shares a _lot_ of the symptomology from fatigue to cardiac issues that #longcovid does. https://t.co/V61Fp4ayKb
@TomKindlon I would add sinus arrythmia and various heart dysfunction to the CFS pile. There are some pretty unique covid symptoms, covid toes/rash, and burning lungs. But a _lot_ shared. https://t.co/V61Fp4ayKb
@ClaireHastie1 @ellecalendula @TomKindlon There are coagulopathy driven problems - stroke/PE - but cardiac issues have been shown in CFS. https://t.co/V61Fp4ayKb https://t.co/gGUa7hszwE https://t.co/VLmdHsGXiP https://t.co/M4uuRd3xPf
@PHOSP_COVID @ScienceMagazine @jcouzin @dr_michaelmarks @ProfJDChalmers @REvans_Breathe @LouiseVwain I note that many of these symptoms, including cardiac issues, are found in most patients with CFS. https://t.co/V61Fp3SXlB https://t.co/gYF7Iw1N2H #mecfs #longcovid
With the attention paid to cardiac symptoms post-covid-19-acute phase, and the similarity of fatigue course to #mecfs in #longcovid I note this 2009 paper finding sinificant cardiac abnormality in #cfs https://t.co/V61Fp4ayKb #covid19 https://t.co/K1GMIyZDxZ
In male mice
At least the mice appear in the title. Some University Medical Center press releases and research articles have buried the mice down in the 16th paragraph, facilitating the illusion that the study was immediately relevant to humans. https://t.co/647l7G3imk
Vietnam, one of the 1st countries that contained SARS in 2003 put emphasis on ventilation at the earliest stage. No HCW was infected in Bach Mai Hospital that kept windows open.
#COVIDisAirborne #ventilation
https://t.co/ht1qns3buo https://t.co/ys5S4t3yiV