著者

荻野 敏 入船 盛弘 後藤 啓恵 仙波 治 野入 輝久

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.92, no.3, pp.309-324, 1999-03-01

参考文献数

13

被引用文献数

4

---

The clinical efficacy and safety of 200 &mu;g/day (100&mu;g b. i. d) of mometasone furoate nasal spray (MFNS) administered for 2 weeks was evaluated by comparison with a low dose of MFNS of 50&mu;g/day (50&mu;g o. d.) using the envelope-method in a total of 65 patients with Japanese cedar<br>pollenosis.<br>The pollen counts for Japanese cedar in 1995 were extremely high in the Kansai district. About 5, 000 counts/cmz was confirmed in and around Osaka.<br>In the analysis of final overall improvement, marked or moderate improvement was observed in 76.2% (16/21) and 20.8% (5/24) of patients receiving MFNS 200&mu;g/day and 50&mu;g/day, respectively. The difference in efficacy between the two dosage groups was confirmed independently of timing of the initiation of administration. In the analysis of overall safety, high safety was observed with both treatments. The above results suggest that 200&mu;g/day of MFNS can be considered the recommended dose for the treatment of Japanese cedar pollenosis.