著者

手嶋 秀毅 十川 博

出版者

一般社団法人日本心身医学会

雑誌

心身医学 (ISSN:03850307)

巻号頁・発行日

vol.29, no.2, pp.157-164, 1989-02-01

被引用文献数

7

---

In order to clarify the influence of emotional stress on T cells, we examined changes in the ratios of T cell subsets in the stressed mice, the patients with alopecia areata, and the student nurses before taking examinations for the national license. T cell subsets were measured using by flowcytometry and fluorescent monoclonal antibodies. The results are as follows. (1) In the restriction stressed mice, the ratio of T cell subsets are changed in the peripheral blood and the thymic gland. Percentage of suppressor T cells was decreased in the stressed mice and the changes are removed by administration of diazepam before restriction. (2) After administration of the autonomic drugs, adrenalin, acetylcholine, yohinbin and hydrocortisone, the ratios of T cell subsets are changed in the peripheral blood of mice. (3) In the peripheral blood of patients with alopecia areata, the ratio of the helper T cells to suppressor T cells is changed to be high during existance of uncontroled aloperia. But in the improved patients after psychotherapy, the ratio is decreased to the normal level. (4) After the examination stress, the ratio of OKT 8 positive cells is found to be elevated in the peripheral blood significantly. Other somatic parameters responsed to the examination stress.