著者
伊丹 仁朗 昇 幹夫 手嶋 秀毅
出版者
一般社団法人日本心身医学会
雑誌
心身医学 (ISSN:03850307)
巻号頁・発行日
vol.34, no.7, pp.565-571, 1994-10-01
被引用文献数
9

This experiment was conducted to clarify the influence of laughter on the immune system. Nineteen volunteer subjects were taken to a variety theater to experience laughter for three hours. Blood samples were taken from the subjects immediately before and after the performance. The NK activity and CD 4/8 ratio of these blood samples were examined. Without exception, in those subjects with NK activity levels which were below average before the performance, there was a significant increase in these activity levels, and in the CD 4/8 ratiosimmediately after the performance (p<0. 05,Wilcoxon's rank-sum test). In all the subjects who had CD 4/8 ratios that were above the standard level immediately before the performance, there was a significant decrease of these ratios immediately after the performance (p<0. 05,t-test). From these findings it is concluded that laughing increases the NK activity of people whose ac- tivity levels are below average and normalizes the CD 4/8 ratios of people whose ratios are above or below the standard levels.

1 0 0 0 OA 笑いと免疫能

著者
伊丹 仁朗 昇 幹夫 手嶋 秀毅
出版者
一般社団法人 日本心身医学会
雑誌
心身医学 (ISSN:03850307)
巻号頁・発行日
vol.34, no.7, pp.565-571, 1994-10-01 (Released:2017-08-01)
被引用文献数
4

This experiment was conducted to clarify the influence of laughter on the immune system. Nineteen volunteer subjects were taken to a variety theater to experience laughter for three hours. Blood samples were taken from the subjects immediately before and after the performance. The NK activity and CD 4/8 ratio of these blood samples were examined. Without exception, in those subjects with NK activity levels which were below average before the performance, there was a significant increase in these activity levels, and in the CD 4/8 ratiosimmediately after the performance (p<0. 05,Wilcoxon's rank-sum test). In all the subjects who had CD 4/8 ratios that were above the standard level immediately before the performance, there was a significant decrease of these ratios immediately after the performance (p<0. 05,t-test). From these findings it is concluded that laughing increases the NK activity of people whose ac- tivity levels are below average and normalizes the CD 4/8 ratios of people whose ratios are above or below the standard levels.
著者
入江 正洋 山下 高範 久保 千春 木原 廣美 中野 博 川村 治子 十川 博 手嶋 秀毅 中川 哲也
出版者
The Japanese Respiratory Society
雑誌
日本胸部疾患学会雑誌 (ISSN:03011542)
巻号頁・発行日
vol.30, no.5, pp.930-934, 1992-05-25 (Released:2010-02-23)
参考文献数
21
被引用文献数
1

症例は19歳の女性. 気管支喘息として約1年10ヵ月, ステロイド剤を含む治療を受けたが, 改善しないため当科に入院した. 患者はアレルギー疾患の家族歴を有し, アストグラフでも気道過敏性があるように思われたものの, 喘鳴出現時に1秒量やPaO2の低下はなく, 気管支拡張剤の吸入でも呼吸機能に変化はみられず, 喘息は否定的であった. また, 患者の喘鳴は喉頭部で最も著明に聴取され, 多くは吸気性の呼吸困難を伴い, フローボリューム曲線は, 吸気時の流速が低下していた. さらに, Laryngos-copy では, 声帯の内転位固定と後方の僅かな間隙が認められ, 以上の所見より Vocal cord dysfunction と診断された. 本症例の喘鳴は, 不幸な生育歴を背景とする転換反応に起因するものと考えられ, 心身相関の理解やセルフコントロールの習得を中心とする心身医学的治療によって, 薬剤不要な状態にまで改善した.
著者
手嶋 秀毅 十川 博
出版者
一般社団法人日本心身医学会
雑誌
心身医学 (ISSN:03850307)
巻号頁・発行日
vol.29, no.2, pp.157-164, 1989-02-01
被引用文献数
7

In order to clarify the influence of emotional stress on T cells, we examined changes in the ratios of T cell subsets in the stressed mice, the patients with alopecia areata, and the student nurses before taking examinations for the national license. T cell subsets were measured using by flowcytometry and fluorescent monoclonal antibodies. The results are as follows. (1) In the restriction stressed mice, the ratio of T cell subsets are changed in the peripheral blood and the thymic gland. Percentage of suppressor T cells was decreased in the stressed mice and the changes are removed by administration of diazepam before restriction. (2) After administration of the autonomic drugs, adrenalin, acetylcholine, yohinbin and hydrocortisone, the ratios of T cell subsets are changed in the peripheral blood of mice. (3) In the peripheral blood of patients with alopecia areata, the ratio of the helper T cells to suppressor T cells is changed to be high during existance of uncontroled aloperia. But in the improved patients after psychotherapy, the ratio is decreased to the normal level. (4) After the examination stress, the ratio of OKT 8 positive cells is found to be elevated in the peripheral blood significantly. Other somatic parameters responsed to the examination stress.