著者

相本 太刀夫 平田 巳円男 平木 優子 土手 千恵子 井上 直人 今井 公江

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.114, no.2, pp.89-93, 1994-02-25

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The antioxidative effect of the mammalian liver hydrolyzate preparation (LH) was investigated mainly in the mouse liver homogenates. At lower concentrations, LH stimulated lipid peroxidation induced by Fe^<2+> and ascorbic acid in the homogenates, but inhibited completely the oxidation at higher concentrations. LH also inhibited the peroxidation of linolenic acid and linoleic acid. LH reduced 1,1-diphenyl-2-picrylhydrazyl, a free radical model, in a concentration-dependent manner, suggesting that the radical scavenging property of LH is involved in its antioxidative action. Fe^<2+> and glutathione, contained in LH, seem to act as a stimulator and an inhibitor of peroxidation, respectively.