1 0 0 0 OA 医薬品と食物繊維との相互作用 ―In Vitro における医薬品の食物繊維への吸着―
- 著者
- 渡邉 真一 井上 直人 今井 公江 末丸 克矢 荒木 博陽 相本 太刀夫
- 出版者
- 一般社団法人日本医療薬学会
- 雑誌
- 医療薬学 (ISSN:1346342X)
- 巻号頁・発行日
- vol.32, no.3, pp.221-226, 2006-03-10 (Released:2007-11-09)
- 参考文献数
- 21
- 被引用文献数
- 9 11
Interest in dietary fiber has been growing due to the many benefits it has for health. It is well known that dietary fiber reduces the risk of developing health problems such as obesity, hypertension, constipation, type 2 diabetics and hyperlipidemia. However, dietary fiber is also known to reduce the bioavailability of minerals, nutrients and certain drugs, though the interaction between dietary fiber and drugs is still poorly understood. In this study, we examined the adsorption of drugs (theophylline, acetaminophen, metoprolol, chlorpromazine, imipramine, amitriptyline and diclofenac sodium) onto several types of dietary fiber (cellulose, chitosan, pectin, sodium alginate and glucomannan) at pH 3 and pH 7 in order to determine the in vitro adsorption characteristics of dietary fiber. Our findings indicated that adsorption of drugs onto dietary fiber ranged from 0 to 96%, varying with the types of dietary fiber and drugs, and pH. Chlorpromazine, imipramine and amitriptyline showed particularly marked adsorption onto sodium alginate and glucomannan. We considered that ionic bonding was one of the reasons for adsorption.These findings indicate the possibility of the bioavailability of drugs being reduced when they are taken with dietary fiber due their adsorption onto dietary fiber.
1 0 0 0 OA 哺乳動物肝臓加水分解物の抗脂質過酸化作用
- 著者
- 相本 太刀夫 平田 巳円男 平木 優子 土手 千恵子 井上 直人 今井 公江
- 出版者
- 公益社団法人日本薬学会
- 雑誌
- 藥學雜誌 (ISSN:00316903)
- 巻号頁・発行日
- vol.114, no.2, pp.89-93, 1994-02-25
The antioxidative effect of the mammalian liver hydrolyzate preparation (LH) was investigated mainly in the mouse liver homogenates. At lower concentrations, LH stimulated lipid peroxidation induced by Fe^<2+> and ascorbic acid in the homogenates, but inhibited completely the oxidation at higher concentrations. LH also inhibited the peroxidation of linolenic acid and linoleic acid. LH reduced 1,1-diphenyl-2-picrylhydrazyl, a free radical model, in a concentration-dependent manner, suggesting that the radical scavenging property of LH is involved in its antioxidative action. Fe^<2+> and glutathione, contained in LH, seem to act as a stimulator and an inhibitor of peroxidation, respectively.