著者

石井 康子 谷澤 久之 池本 長司 滝野 吉雄

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.101, no.3, pp.254-258, 1981

被引用文献数

4 7

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Cathartic effects of Aloe pulv. (J. P. IX) and pulv. of Aloe arborescens MILL. var. natalensis BERGER (Kidachialoe) were examined in mice and rats by oral administration. It was found that rats were more suitable than mice. Additionally, no sex difference in rats was observed. Cathartic activity (ED<SUB>50</SUB>) in male rats was 84.3 mg/kg in Aloe pulv., and 900 mg/kg in Kidachialoe pulv. Several experiments to find the mechanism of cathartic effect of Aloe were done. It was considered that Aloe acted on the large intestine mainly, and that process of activation of Aloe by intestinal flora was necessary to act. It was considered that main cathartic component of Aloe was barbaloin by comparision of barbaloin contents in Aloe and cathartic activity. Then, it was concluded that barbaloin represented cathartic activity of Aloe.