著者

石井 康子 梅原 薫 野毛 一郎 加藤 有希

出版者

静岡県立大学

雑誌

挑戦的萌芽研究

巻号頁・発行日

2012-04-01

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吃逆の治療に使われる柿蔕(Kaki Calyx)のラット脳脊髄液中神経伝達物質に及ぼす影響を検討したところ、GABAの変動は観察されなかったが、アスパラギン酸やグリシン、更に、ドパミンの代謝物であるDOPACやHVA濃度に影響を及ぼすことが示唆された。今後、これらを指標として、日本産の柿の蔕から有効成分の探索を行う予定である。また、柿蔕液の治療効果を処方の異なる施設で後ろ向きに調査したところ、化学療法の施行により発症する吃逆の治療に、高濃度の柿蔕液の服用が適している可能性が示唆されたため、前向き調査によって確認する予定である。

著者

石井 康子 谷澤 久之 池本 長司 滝野 吉雄

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.101, no.3, pp.254-258, 1981

被引用文献数

4 7

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Cathartic effects of Aloe pulv. (J. P. IX) and pulv. of Aloe arborescens MILL. var. natalensis BERGER (Kidachialoe) were examined in mice and rats by oral administration. It was found that rats were more suitable than mice. Additionally, no sex difference in rats was observed. Cathartic activity (ED<SUB>50</SUB>) in male rats was 84.3 mg/kg in Aloe pulv., and 900 mg/kg in Kidachialoe pulv. Several experiments to find the mechanism of cathartic effect of Aloe were done. It was considered that Aloe acted on the large intestine mainly, and that process of activation of Aloe by intestinal flora was necessary to act. It was considered that main cathartic component of Aloe was barbaloin by comparision of barbaloin contents in Aloe and cathartic activity. Then, it was concluded that barbaloin represented cathartic activity of Aloe.

著者

石井 康子

出版者

静岡県立大学

巻号頁・発行日

1994

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博士論文

著者

石井 康子 谷澤 久之 滝野 吉雄

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.108, no.9, pp.904-910, 1988-09-25

被引用文献数

4

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The mechanism of cathartic effect of barbaloin, representative of Aloe, was investigated by using male rats. Barbaloin administered orally was demonstrated to decompose to aloe-emodin-9-anthrone and aloe-emodin in the rat large intestine. And, these decomposed compounds were likely to change each other in the large intestine. Any compound of barbaloin, aloe-emodin-9-anthrone and aloe-emodin administered orally to rats was found to cause an obvious increase of water content in the large intestine, and only aloe-emodin-9-anthrone administered orally caused a significant increase of water content in the small intestine. Furthermore, the clear increase of water content and abnormality of electrolytes (Na^+, K^+) in the colon segment of rat were observed only by aloe-emodin-9-anthrone when compounds tested were injected directly into the colon segment. Therefore, it seemed that aloe-emodin-9-anthrone, a decomposition product of babaloin in the rat large intestine, caused an increase of water content in the large intestine by a different mechanism from the stimulation of peristalsis and this played an important role in cathartic activity of barbaloin.