著者

入谷 信彦 滝野 吉雄 谷沢 久之

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.87, no.9, pp.1128-1131, 1967-09-25 (Released:2008-05-30)

参考文献数

11

---

4-Iodothymol was reduced with zinc dust in acetic acid and iodide ion produced was titrated with potassium iodate standard solution in the presence of hydrogen cyanide. By the visual titration, 20∼100 mg. of 4-iodothymol was determined using chloroform as an indicator and 2∼20 mg. was determined by the dead stop end point titration. Results obtained show that both methods are found to be enough accurate and precise for the determination. The determination had no interference by thymol and surface active agents contained in anthelminthic preparations of 4-iodothymol.

著者

石井 康子 谷澤 久之 池本 長司 滝野 吉雄

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.101, no.3, pp.254-258, 1981

被引用文献数

4 7

---

Cathartic effects of Aloe pulv. (J. P. IX) and pulv. of Aloe arborescens MILL. var. natalensis BERGER (Kidachialoe) were examined in mice and rats by oral administration. It was found that rats were more suitable than mice. Additionally, no sex difference in rats was observed. Cathartic activity (ED<SUB>50</SUB>) in male rats was 84.3 mg/kg in Aloe pulv., and 900 mg/kg in Kidachialoe pulv. Several experiments to find the mechanism of cathartic effect of Aloe were done. It was considered that Aloe acted on the large intestine mainly, and that process of activation of Aloe by intestinal flora was necessary to act. It was considered that main cathartic component of Aloe was barbaloin by comparision of barbaloin contents in Aloe and cathartic activity. Then, it was concluded that barbaloin represented cathartic activity of Aloe.

著者

谷澤 久之 佐塚 泰之 小松-芹田 明子 滝野 吉雄

出版者

公益社団法人 日本栄養・食糧学会

雑誌

日本栄養・食糧学会誌 (ISSN:02873516)

巻号頁・発行日

vol.36, no.4, pp.283-289, 1983 (Released:2010-02-22)

参考文献数

12

被引用文献数

8 5

---

米酢は米よりつくる醸造酢の一種であり, 単なる食用酢としてではなく, 東洋では民間薬として健康維持に役立ってきた歴史を持っている。著者らは, マウスを用い急性毒性と脂質代謝に及ぼす影響を検討した。その結果, 1) マウスでの急性毒性は21.5ml/kg (p. o.) でその死因は含有する酢酸による上部消化管に対する障害作用に基づくことが認められた。2) 通常食および高コレステロール食で飼育したマウスの血清コレステロール値を米酢は 2.5ml/kg (p. o.) 以上で低下させた。また, 4%酢酸水溶液でも, ほぼ同様の効果が認められた。3) 抗生物質アドリアマイシソによる心臓中の過酸化脂質 (LPO) 上昇に対し, 米酢は2.5ml/kg (p. o.) で抑制した。また, 正常マウス心臓中のLPOも5ml/kg (p. o.) 以上で低下させた。一方, 4%酢酸水溶液のこれらLPOに対する作用は弱いものだった。

著者

石井 康子 谷澤 久之 滝野 吉雄

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.108, no.9, pp.904-910, 1988-09-25

被引用文献数

4

---

The mechanism of cathartic effect of barbaloin, representative of Aloe, was investigated by using male rats. Barbaloin administered orally was demonstrated to decompose to aloe-emodin-9-anthrone and aloe-emodin in the rat large intestine. And, these decomposed compounds were likely to change each other in the large intestine. Any compound of barbaloin, aloe-emodin-9-anthrone and aloe-emodin administered orally to rats was found to cause an obvious increase of water content in the large intestine, and only aloe-emodin-9-anthrone administered orally caused a significant increase of water content in the small intestine. Furthermore, the clear increase of water content and abnormality of electrolytes (Na^+, K^+) in the colon segment of rat were observed only by aloe-emodin-9-anthrone when compounds tested were injected directly into the colon segment. Therefore, it seemed that aloe-emodin-9-anthrone, a decomposition product of babaloin in the rat large intestine, caused an increase of water content in the large intestine by a different mechanism from the stimulation of peristalsis and this played an important role in cathartic activity of barbaloin.