著者

宮田 知幸

出版者

岐阜大学

雑誌

岐阜大学医学部紀要 (ISSN:00724521)

巻号頁・発行日

vol.51, no.1, pp.157-162, 2003-03-31

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Purpose Intercellular adhesion molecule-1 (ICAM-1) expressed on colorectal carcinoma was reported to be related to grades of its malignancy. The purpose of this study was to investigate whether the distribution of ICAM-1 expression in colorectal carcinoma correlated with their pathological findings and prognoses after surgical resection. Materials and Methods Forty-two patients with colorectal carcinoma underwent surgical resection. Their ICAM-1 in colorectal carcinoma was stained with immunohistchemical method. We compared the distribution of ICAM-1 with pathological stages, tumor diameter, tumor infiltration depth and vessels involvement, lymph node and liver metastasis, peritoneal dissemination, and survival after surgical resection, respectively. Results The distribution of ICAM-1 expression were classified into three types : Type D or diffuse type, Type I or intermediate type and Type S or sporadic type. Tumor diameter in Type D, I and S were 5.9±1.4, 9.2±2.5 and 3.3±1.2cm, respectively (p<0.0001). Tumor diameter in patients (DL : n= 6) who survived longer than 5 years after surgery and those (DD : n=14) who died with in 5 years, in Type D and those (SL : n=10) who survived longer than 5 years and those (SD : n=4) who died within 5 years, in Type S were 5.1±1.3, 6.2±1.4, 2.9±1.0 and 4.1±1.1cm, respectively (p<0.0001). The grade of lymph node metastasis was SD, DD, SL and DL in order (p<0.0089). SL was significantly different from DD (p<0.0349). There were no significant relations between the distribution of ICAM-1 expression and other parameters. Conclusion These results suggest that the distribution of ICAM-1 expression is useful as an index for survival of the patients with surgical resection of colorectal carcinoma.