著者

紺野 勝弘 白浜 晴久 松本 毅

出版者

天然有機化合物討論会

雑誌

天然有機化合物討論会講演要旨集

巻号頁・発行日

no.25, pp.421-428, 1982-09-10

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Clitocybe acromelalga is a poisonous mushroom distributed in Japan only. It exhibits unique toxicity. If one takes it accidentaly, one will have intolerable pain in fingers and toes after some days and the pain continues for about a month. We were interested in these remarkable physiological activities. It was difficult to reproduce the above described symptoms in experimental animals, however. So we fractionated various constituents of the mushroom testing the lethal effect on mice. Clitidine was a weakly toxic, a new nucleoside. Clithioneine, an unusual betaine, was nontoxic. From the most toxic fraction, acromelic acid A (ca. 110μg) and acromelic acid B (ca. 40μg) were isolated. We suggest formula 1 and 2 for A and B respectively on the basis of ^1H NMR and UV data.