著者
松本 孝 /若林 ゆう /池田 啓一 /山倉 文幸 若林 ゆう 池田 啓一 Keiichi IKEDA Fumiyuki YAMAKURA
出版者
昭和女子大学近代文化研究所
雑誌
學苑 = GAKUEN (ISSN:13480103)
巻号頁・発行日
vol.818, pp.35-39, 2008-12-01

Peroxynitrite, which is formed from the reaction of superoxide radical and nitric oxide, can cause specific structural modifications in proteins such as the addition of a nitro group onto aromatic residues. These modifications can cause perturbations in the properties of the proteins, such as conformation, catalytic activity, susceptibility to proteolysis, and immunogenicity, resulting in several human diseases. Finding a specific peroxynitrite scavenger is, therefore, of considerable importance. Accordingly, we assessed the scavenging ability of several biomolecules purchased from commercial sources on nitration of a protein by peroxynitrite at physiologic CO2 condition in vitro. In sixteen molecules tested, reduced redox-cofactors, and polyphenol-compounds were effective scavengers against peroxynitrite-mediated protein nitration in vitro and one of these, epigallocatechine was the most effective. It was also noticed that tryptophan and serotonin creatinine sulfate possessed relatively high scavenging abilities against peroxynitrite-mediated protein nitration in vitro.

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【個人的MCSメモ】⚠️民間療法です ・シトルリン摂取→NO増える(抗酸化作用、血流増加)→MCS、EHS改善 ・オキシド/ペルオキシナイトライト(NO/ONOO-)サイクル  O₂⁻+NO→ONOO⁻ #mcs込 ▽資料1… https://t.co/zhIsiMp1ig

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