著者

井上 正幸 傳 秋光 鳴瀧 恭也

出版者

一般社団法人 日本糖尿病学会

雑誌

糖尿病 (ISSN:0021437X)

巻号頁・発行日

vol.37, no.7, pp.499-502, 1994

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Using gas chromatographic mass spectrometry, we identified cholesteryl-6 (2, 6-di-tertialy butylphenol-4)-thioether (CT) in the urine of diabetics with hypercholesterolemia who were being treated with oral glibenclamide, 2.5 mg, and probucol, 500 mg/day.<BR>Presumably probucol was hydrolyzed to form 4-mercapto-2, 6-di-tertialy-butylphenol (MBP), the MBP reacted with cholesterol-5 &alpha;, 6 &alpha;-epoxide, oxidized cholesterol, and CT was then formed as a result of dehydration and condensation reactions.<BR>Probucol is expected to be useful in preventing diabetic macroangiopathy and removing oxidized cholesterol from the plasma into the urine.