- 著者
-
井上 正幸
傳 秋光
鳴瀧 恭也
- 出版者
- 一般社団法人 日本糖尿病学会
- 雑誌
- 糖尿病 (ISSN:0021437X)
- 巻号頁・発行日
- vol.37, no.7, pp.499-502, 1994
Using gas chromatographic mass spectrometry, we identified cholesteryl-6 (2, 6-di-tertialy butylphenol-4)-thioether (CT) in the urine of diabetics with hypercholesterolemia who were being treated with oral glibenclamide, 2.5 mg, and probucol, 500 mg/day.<BR>Presumably probucol was hydrolyzed to form 4-mercapto-2, 6-di-tertialy-butylphenol (MBP), the MBP reacted with cholesterol-5 α, 6 α-epoxide, oxidized cholesterol, and CT was then formed as a result of dehydration and condensation reactions.<BR>Probucol is expected to be useful in preventing diabetic macroangiopathy and removing oxidized cholesterol from the plasma into the urine.