著者

陳 明裕 藤田 邦夫 石井 準之助 島田 桂吉 平田 たつみ 藤澤 肇

出版者

特定非営利活動法人 日本レーザー医学会

雑誌

日本レーザー医学会誌 (ISSN:02886200)

巻号頁・発行日

vol.12, pp.269-272, 1991

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We applied low power laser irradiation on cultured dorsal root ganglion (DRG) which was excised from mouse, Continuous wave Ga-Al-As diode laser of 830nm wave length and 20mW power output was irradiated for 5-15 minutes. Neurite elongation from DRG was inhibited significantly by laser irradiation. It also inhibited neurite elongation of single neuron isolated from DRG. Especially that of small diameter neuron was significantly inhibited.<BR>By immunostaining, neurites including substance P and/or CGRP were shown to he affected severely. These results suggest that inhibitory effect of laser irradiation on neurite elongation may relate to the mechanism of pain attenuation.