著者
小野 百合 三沢 和史 工藤 守 岡崎 裕子 天日 和子 中川 昌一 近藤 光
出版者
The Japanese Society on Thrombosis and Hemostasis
雑誌
血液と脈管 (ISSN:03869717)
巻号頁・発行日
vol.18, no.4, pp.343-346, 1987

The prevention of diabetic microangiopathy, especially retinopathy, is the last goal of treatment of diabetic patients. Retinopathy is found to progress following rapid control of blood glucose or surgical treatment. To investigate the deterioration of retinopathy, the changes of platelet aggregation induced by ADP, collagen, PAF and epinephrine, of the arachidonate cascade (TXB<sub>2</sub> and 6-keto PGF<sub>1α</sub>), and of blood viscosity were measured during and after surgical treatment or after rapid control of blood glucose. Blood was obtained from 22 diabetics with rapid control of blood glucose and from 11 diabetics undergoing surgical treatment.<br>Platelet aggregation induced by all aggregators was increased after rapid control of blood glucose and after surgical treatment, but decreased during operation. When platelet aggregation before surgical treatment was exaggerated, retinopathy tended to be worsened after surgical treatment. Concerning the arachidonate cascade, both TXB<sub>2</sub> and 6-keto PGF<sub>1α</sub> were increased and the TX/6-keto PGF<sub>1α</sub> ratio was decreased during operation.

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こんな論文どうですか? 糖尿病患者の網膜症増悪時の血小板凝集能の変化  急速な血糖是正時,および手術時の変化について:急速な血糖是正時, および手術時の変化について(小野 百合ほか),1987 https://t.co/su0f6L3HAo

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