著者

檀上 泰 宮川 清彦 石塚 玲器 田中 信義 佐藤 知義 福本 徹

出版者

一般社団法人 日本血栓止血学会

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.3, no.4, pp.401-409, 1972-04-25 (Released:2010-08-05)

参考文献数

11

著者

中村 晴臣 嘉本 崇也

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.7, no.4, pp.261-267, 1976-04-25 (Released:2010-08-05)

参考文献数

11

被引用文献数

1

著者

山本 信二郎 埴生 知則 林 実

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.6, no.7, pp.543-550, 1975-07-25 (Released:2010-08-05)

参考文献数

24

著者

毛利 喜久男 恒川 謙吾

出版者

一般社団法人 日本血栓止血学会

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.1, no.6, pp.753-762, 1970-08-25 (Released:2010-08-10)

参考文献数

14

著者

松尾 博司

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.7, no.5, pp.363-366, 1976-05-25 (Released:2010-08-05)

参考文献数

3

著者

金子 弘真 高塚 純 柴 忠明 竹内 節夫 斉藤 徹 五十嵐 紀子 浅田 敏雄

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.15, no.3, pp.274-276, 1984-06-01 (Released:2010-08-05)

参考文献数

7

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(Multiple organ failure) MOF or (Disseminated intravascular coagulation) DIC often becomes a fatal complication for the patients suffering from endotoxin shock. And it is also pointed out that MOF and DIC share many common or simiar clinical features. To clarify the relationship between these two, we surveyed the changes in haematological indices of organ failure patient.DIC was complicated in 10 of 14 patients with endotoxin shock and 9 of these were victimized. In the latter 9 cases, failure of more than three organs occured concomitantly. DIC observed in patients with organ failure is as follows: 10 in 13 cases of lung failure, 3 in 5 cases of heart failure, 10 in 12 cases of renal failure, 3 in 5 cases of liver failure and 3 in 4 cases of gastro-intestinal bleeding. Both organ failure and DIC usually began at the lung in endotoxin shock patients. From the viewpoint of haematology, hypercoagulable tendency preceded the lung failure. For example, decrease in antithrombin III and plasminogen level was observed prior to that in platelet.In endotoxin shock patients, MOF and DIC have close relationship, which suggests that hypercoagulable state induced by endotoxin triggers an organ failure and results in MOF through chain reactions.

著者

大国 真彦

出版者

一般社団法人 日本血栓止血学会

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.5, no.7, pp.557-562, 1974-07-25 (Released:2010-08-05)

参考文献数

4

著者

中島 茂 東松 豊彦 服部 浩明 岡野 幸雄 野沢 義則

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.17, no.1, pp.59-61, 1986-02-01 (Released:2010-08-05)

参考文献数

10

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In many secretory cells, cyclic nucleotides and Ca2+ cooperatively or antagonistically control cell responses. Activation of platelets with thrombin caused a rapid breakdown of phosphoinositides and an increase of cytoplasmic free Ca2+ concentration, which resulted in shape change, secretion and aggregation. The hypothetical concept has recently been proposed that inositol trisphosphate, a degradation product of phosphatidylinositol 4, 5-bisphosphate (PIP2), serves as a second messenger for mobilizing intracellular Ca2+. The effects of cAMP and cGMP on thrombin-induced human pletelet responses were investigated. Thrombin-induced serotonin secretion and aggregation were inhibited by pretreatment with dibutyryl cAMP (dbcAMP) or 8-bromo cGMP (8bcGMP) in a dose-dependent manner. However, shape change was not affected by 8bcGMP. Preincubation of platelets with dbcAMP or 8bcGMP was without effect on the basal level of inositol trisphosphate and free cytosolic Ca2+, measured by fluorescent indicator quin 2, but suppressed their thrombin-induced enhancements. Enhanced [32P] incorporation into phosphatidylinositol 4-phosphate (PIP) and PIP2 was observed with dbcAMP or 8bcGMP treatment, suggesting activation of PI- and PIP-kinases. These results indicate that cGMP as well as cAMP acts as a negative messenger to prevent platelet activation. The inhibitory effect can be explained at least in part by the repression of phospholipase activation, resulting in reduced formation of inositol trisphosphate.

著者

内野 治人

出版者

一般社団法人 日本血栓止血学会

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.1, no.8, pp.1085-1099, 1970-10-25 (Released:2010-08-10)

参考文献数

21

被引用文献数

1

著者

池田 正男 村田 和彦

出版者

一般社団法人 日本血栓止血学会

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.2, no.5, pp.671-676, 1971-05-25 (Released:2010-08-10)

参考文献数

20

著者

三浦 健

出版者

一般社団法人 日本血栓止血学会

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.1, no.9, pp.1181-1193, 1970-11-25 (Released:2010-08-05)

参考文献数

14

著者

吉田 豊 木村 あさの 黒江 清郎 外村 紀知也

出版者

一般社団法人 日本血栓止血学会

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.2, no.5, pp.753-757, 1971

著者

桜川 信男 湯浅 和典 近藤 信一 丹羽 正弘 横田 力

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.14, no.2, pp.228-230, 1983-06-01 (Released:2010-08-05)

参考文献数

5

---

Crude drugs of Wakan-Yakus (traditional herbal drugs) such as Gaiyoh (Artemisiae folium), Sanshishi (Gardeniae fructus), Taiso (Zizyphi fructus), Kizutsu (Aurantii fructus immaturus) and Akyoh (Glutinum) were investigated to analyse the effects on blood coagulation system.(1) Gaiyoh (Artemisiae folium) showed the effects of anticoagulant, antifibrinolytic and anti-platelet aggregation, and the anticoagulant effect was strong prominently. When the crude drug of Gaiyoh was purified by the Sephadex G-100 column chromatography, four peaks were found. The strong antocoagulant effect was found to the third peak. We settled “Inhibition unit” of Gaiyoh from statistic studies, and 2.5mg/ml of Gaiyoh in the final concentration was evaluated to be 10 inhibition units.(2) Sanshishi (Gardeniae fructus) showed strong fibrinolytic effect characteristically.

著者

長谷川 嗣夫

出版者

一般社団法人 日本血栓止血学会

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.4, no.4, pp.413-419, 1973-04-25 (Released:2010-08-05)

参考文献数

35

著者

溝口 秀昭

出版者

一般社団法人 日本血栓止血学会

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.3, no.11, pp.1211-1212, 1972-11-25 (Released:2010-08-10)

参考文献数

2

著者

佐藤 敬 高松 滋 作田 茂 水野 成徳 高松 むつ 武田 俊平

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.13, no.3, pp.410-413, 1982-09-01 (Released:2010-08-05)

参考文献数

3

---

The effects of mefenamic acid on in vitro platelet functions, namely thrombininduced production of thiobarbituric acid-reactive substances (TBARS) and ADP-induced platelet aggregation, were investigated and compared with those of aspirin and flurbiprofen.Mefenamic acid inhibited platelet TBARS production almost comparatively to aspirin and flurbiprofen. The inhibitory effects of these three drugs on platelets from patients with atherosclerotic vascular diseases were smaller than the effects on platelet from normal subjects. Percent inhibition, by mefenamic acid, on platelet TBARS production correlated positively with maximal aggregation in these subjects.Mefenamic acid also strongly suppressed platelet aggregation. In contrast to aspirin and flurbiprofen, of which effects were limited solely on secondary aggregation, mefenamic acid abolished primary aggergation, as well. Therefore, besides being a strong inhibitor of platelet thromboxane generation, mefenamic acid may exert its anti-platelet action through unknown mechanism (s). Antiplatelet action of this drug can be also characterized by the result suggesting that the inhibition tends to be large on platelets with higher aggregatory activity.

著者

松田 保 小河原 緑 三浦 玲子 関 俊子

出版者

一般社団法人 日本血栓止血学会

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.15, no.2, pp.207-209, 1984

被引用文献数

1

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Levels of fibrinogen, plasminogen, antithrombin III, &alpha;₂-plasmin inhibitor and &alpha;₂-macroglobulin in plasma were determined using single radial immunodiff usion method in an old people's home in 1979, 1981 and 1982. Comparison of results of these parameters in the same subjects between in 1981 and 1982 was possible in 67 subjects. Comparison between in 1979 and 1981 was done in 61 subjects. Results of coagulation analysis in 1979 and 1982 were compared in 49 subjects.<br>Generally, concentrations of plasminogen, antithrombin III and &alpha;₂-plasmin inhibitor in plasma were higher in women than in men. There were statistically significant correlations between all the parameters determined at intervals of 1, 2 and 3 years in the same subjects. The coefficients of correlation in each parameter at intervals of 1 to 3 years were as follows: +0.45-+0.57 in fibrinogen, +0.69-+0.81 in plasminogen, +0.55-+0.81 in antithrombin III, +0.46-+0.64 in &alpha;₂-plasmin inhibitor and +0.91-+0.93 in alpha;₂-macroglobulin. From these results, it is concluded that old women are generally less thrombotic than old men and that there is some &ldquo;individuality&rdquo; in patterns of the parameters affecting blood coagulation and fibrinolysis in the elderly. The significance of the &ldquo;individuality&rdquo; upon prognosis of the elderly was discussed.

著者

松田 保 小河原 緑 平林 直子 関 俊子 横内 正利 村上 元孝 島田 馨 三船 順一郎

出版者

一般社団法人 日本血栓止血学会

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.9, no.2, pp.208-212, 1978

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Recently, growing interests had been devoted largely to disseminated intravascular coagulation (DIC), because of its frequency and clinical importance. It has been known that shock is a frequent complication of DIC, although it has not been elucidated whether shock is a cause of DIC rather than a result. This study was made to clarify relationship between DIC and shock in 699 consecutive autopsied cases, almost all of whom was over age sixty, in Tokyo Metropolitan Geriatric Hospital.<br>The diagnosis of DIC was established when coagulation analysis revealed presence of consumption coagulopathy. Among these cases, 106 had evidences of DIC and 30 had clinical and pathological findings highly suggestive of DIC although the coagulation findings were not specific. Shock was complicated in 38 of the former and 10 of the latter.<br>Eight of these 48 patients with DIC complicated with shock revealed consumption coagulopathy simultaneously with the development of shock. 24 cases had not clea r-cut evidences of DIC immediately after the development of shock in coagulation findings, although they showed marked coagulation abnormalities indicating DIC after the shock developed. 44% of conditions associated with the shock in these patients was gram-negative septicaemia. The other underlying pathologic conditons in these cases consisted of cancer, peptic ulcer, acute myocardial infarction and pneumonia.<br>Onset of shock was observed in 16 cases in whom diagnosis of DIC had been already established by coagulation analysis. 11 cases of these had cancer with metastases, primary organs of which were stomach, colon or biliary tracts. 70% of these patients were febrile.<br>Acute renal failure, purpura, petechiae, melena, coma, epileptic seizure, systemic peripheral gangrene and/or red cell fragmentation in peripheral blood smear were main symptoms in DIC with shock. Four cases, excluding two cases in whom DIC developed following development of acute myocardial infarction, showed ECG findings indicating development of acute myocardial infartion, although myocardial infarction was evident in only one cases by postmortem examination.<br>Presence of fibrin thrombi was confirmed in 36 cases out of the 48 autopsied cases with DIC accompained with shock. Terminal hemorrhagic necrotizing enteropathy was observed in 15 of those cases. Hemorrhage from adrenal was observed in 4 cases.<br>From these results, it is concluded that shock does frequently cause DIC and that shock in gram-negative septicaemia is especially important because of its high incidence to result DIC.

著者

松田 保

出版者

一般社団法人 日本血栓止血学会

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.1, no.4, pp.485-495, 1970

著者

松田 保 児玉 直子 秀野 啓子 小河原 緑 松崎 俊久 村上 元孝 山之内 博

出版者

一般社団法人 日本血栓止血学会

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.7, no.2, pp.146-150, 1976

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Apparent blood viscosity was measured on freshly shed blood from 127 healthy subjects, ages 21 to 88, and patients hospitalized in Tokyo Metropolitan Yoikuin Geriatrics Hospital, over age 60. Determination of blood viscosity was performed at 37&deg;C using rotational viscometer at shear rates between 0.07 and 4.6sec^-1.<br>Mean blood viscosity in 43 healthy older subjects over age 60 (mean age: 74&plusmn;6) was 45&plusmn;25cp at 0.07sec^-1 and 8&plusmn;2cp at 4.6sec^-1, respectively. Yield stress was calculated from Casson plot at very low shear rates (between 0.44 and 0.07sec^-1) by the method of least squares. Mean value of yield stress in the healthy older subjects was 0.011 dynes/cm². Blood viscosity in the healthy subjects was significantly correlated with hematocrit values. Yield stress in these subjects was also correlated with hematocrit values and blood viscosity at very low shear rates. In these healthy subjects, blood viscosity, yield stress and hematocrit values were highest in the group at age 30-39. Blood viscosity and yield stress showed a slight decline with age in the healthy older subjects.<br>In the hospitalized patients, blood viscosity was higher than 70cp at 0.07sec^-1, and/or higher than 11cp at 4.6sec^-1 in 107 measurements (86 cases) out of 1443 determinations from December 1973 to October 1974. These patients with blood high viscosity included 12 cases of cancer (one of them was accompanied with disseminated intravascular coagulation (DIC); three of them developed DIC thereafter), 5 cases of acute myocardial infarction, 4 cases of acute cerebral infarction, 5 cases of angina pectoris, 6 cases of old myocardial infarction, 18 cases of old cerebrovascular diseases, 11 cases of diabetes mellitus, and 5 cases of stress polycythemia or polycythemia vera. In these cases, viscosity at 4.6sec^-1 was significantly correlated with hematocrit values, whereas viscosity at 0.07sec^-1 was not. All patients with blood high viscosity and relatively low hematocrit values suffered from cancer. In 6 cases of acute myocardial, cerebral of renal infarction, in whom changes in blood viscosity, yield stress and hematocrits were investigated before and after the development of infarction, changes in blood viscosity and yield stress were parallel with hematocrits.<br>From these results, it was concluded that high hematocrits caused blood high viscosity and were regarded as one of the risk factors in the pathogenesis of thrombosis, although the other factors than hematocrits might also influence blood viscosity at very low shear rates.