著者

小野 百合 三沢 和史 工藤 守 岡崎 裕子 天日 和子 中川 昌一 近藤 光

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.18, no.4, pp.343-346, 1987

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The prevention of diabetic microangiopathy, especially retinopathy, is the last goal of treatment of diabetic patients. Retinopathy is found to progress following rapid control of blood glucose or surgical treatment. To investigate the deterioration of retinopathy, the changes of platelet aggregation induced by ADP, collagen, PAF and epinephrine, of the arachidonate cascade (TXB₂ and 6-keto PGF_1α), and of blood viscosity were measured during and after surgical treatment or after rapid control of blood glucose. Blood was obtained from 22 diabetics with rapid control of blood glucose and from 11 diabetics undergoing surgical treatment.<br>Platelet aggregation induced by all aggregators was increased after rapid control of blood glucose and after surgical treatment, but decreased during operation. When platelet aggregation before surgical treatment was exaggerated, retinopathy tended to be worsened after surgical treatment. Concerning the arachidonate cascade, both TXB₂ and 6-keto PGF_1α were increased and the TX/6-keto PGF_1α ratio was decreased during operation.