著者

美藤 純弘 藤井 昭仁 舩橋 誠 小橋 基 松尾 龍二

出版者

日本生理学会

雑誌

日本生理学会大会発表要旨集

巻号頁・発行日

vol.2007, pp.236-236, 2007

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We showed the glutamatergic, GABAergic and glycinergic synaptic inputs to superior salivatory (SS) neurons which is the primary center of submandibular salivary secretion. This glutamatergic input is considered to derive from the forebrain and brainstem. In the present study, we studied how SS neurons receive the glutamatergic inputs from the forebrain and brainstem in rats. The SS neurons innervating the salivary glands were labeled by retrograde axonal transport of a fluorescent dye. Subsequently some rats were decerebrate. Whole-cell patch-clamp recordings were performed from the labeled cells in slices. Excitatory postsynaptic currents were evoked by electrical stimulation near the recording cell. As compared with normal SS neurons, decerebrate SS neurons showed 3 types of the responses: enhanced responses, similar responses, no responses. The SS neurons which showed enhanced EPSCs receive the excitatory inputs from forebrain and brainstem. Decerebration induced denervation-hypersensitivity in the glutamate receptors. Enhanced EPSCs may be evoked by stimulation of glutamatergic inputs from brainstem. The SS neurons displayed similar responses have mainly excitatory inputs from the brainstem. The SS neurons which displayed no responses produced larger currents by the application of glutamate, suggesting that this type has excitatory inputs exclusively from the forebrain. <b>[J Physiol Sci. 2007;57 Suppl:S236]</b>