文献一覧: 今井良二 (著者)

1 0 0 0 OA Synthesis of Purine Nucleoside Nitrosoureas and Their Antitumor Activities

著者: 佐藤章今井良二中溝喜博平田正
出版者: The Pharmaceutical Society of Japan
雑誌: Chemical and Pharmaceutical Bulletin (ISSN:00092363)
巻号頁・発行日: vol.27, no.3, pp.765-770, 1979-03-25 (Released:2008-03-31)
被引用文献数: 2 5

Guanine and xanthine nucleoside derivatives (3, 4 and 6) bearing nitrosourea functional groups were synthesized from guanine nucleoside ureas (2) obtained by the reaction of 2'-deoxy-2'-aminoguanosine (1) with isocyanates and their antitumor activity against sarcoma-180 solid tumor and leukemia L-1210 were determined. Among the compounds tested, 2'-deoxy-2'-[3-(2-chloroethyl)-3-nitrosoureido]-xanthosine (4b) found to have the most potent activity. Moreover, very slight decrease in white blood cells of mice bearing sarcoma-180 solid tumor was observed after administration of 4b.

2016-05-22 05:17:35
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https://www.jstage.jst.go.jp/article/cpb1958/27/3/27_3_765/_article/-char/ja/
(info:doi/10.1248/cpb.27.765)

1 0 0 0 OA アルミ-水反応の衛星推進系への適用 (室蘭工業大学航空宇宙機システム研究センター年次報告書 2015)

1 0 0 0 OA Synthesis of Purine Nucleoside Nitrosoureas and Their Antitumor Activities