著者

遠藤 きよ子 高橋 まり子 功刀 恵美子 野口 和孝 佐藤 政男

出版者

日本社会薬学会

雑誌

社会薬学 (ISSN:09110585)

巻号頁・発行日

vol.33, no.1, pp.43-50, 2014-06-10 (Released:2015-08-11)

参考文献数

20

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The Fukushima Daiichi Nuclear Power Plant (FDNPP) Accident happened in Fukushima prefecture in March, 2011 and various efforts have been carried out to prevent health damage, including thyroid cancer, caused by radioactive-iodide. In this present report, we tried to discover whether stable-iodide for the prevention against the development of thyroid cancer was properly administered to radioactive-iodide-exposed persons or not. Since pharmacists play an important role in the treatment of stable-iodide, we investigated how the pharmacists in Fukushima contributed to the treatment of stable iodide in the FDNPP accident. In addition, we introduce a new revised method for the treatment of stable iodide published by the Nuclear Regulation Authority, discuss the important role of pharmacists in the Nuclear Power Plant Accident, and propose possible ways of preparation to protect the health of citizens.

著者

佐藤 政男 鈴木 真也

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.127, no.4, pp.703-708, 2007-04-01 (Released:2007-04-01)

参考文献数

16

被引用文献数

6 6

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Much attention has been paid to lifestyle-related diseases including type 2 diabetes mellitus, cardiovascular disease, hypertension, and hyperlipidemia because the incidence rates of these diseases are increasing in developed countries. Elucidation of factors contributing to the development of obesity and insulin resistance is needed. Metallothionein (MT), a ubiquitous metal-binding protein, is induced not only by heavy metals but also by various kinds of stresses. Endoplasmic reticulum (ER) stress is caused by accumulation of misfolded proteins in ER. Recently, increased ER stress by obesity and impairment of insulin action by ER stress have been reported. Exposure to ER stress increased induction of MT synthesis, and an enhanced response to ER stress evaluated as expression of Bip/GRP78mRNA was observed in the liver of MT-null mice, suggesting that MT attenuates expression of ER stress. MT may prevent ER stress and thereby modulate the development of obesity and insulin resistance. A possible role of metallothionein in response reaction for ER stress is discussed.