著者

芥田 憲夫 鈴木 文孝 川村 祐介 八辻 寛美 瀬崎 ひとみ 鈴木 義之 保坂 哲也 小林 正宏 小林 万利子 荒瀬 康司 池田 健次 熊田 博光

出版者

一般社団法人 日本肝臓学会

雑誌

肝臓 (ISSN:04514203)

巻号頁・発行日

vol.47, no.9, pp.450-451, 2006 (Released:2007-01-18)

参考文献数

5

被引用文献数

2 2

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We evaluated 130 consecutive Japanese adults of HCV genotype 1b who received treatment with peginterferon (PEG-IFN) plus ribavirin (RBV) for 48 weeks, to investigate the pretreatment predictive factors of early virologic response (EVR) and sustained virological response (SVR). 75% of patients could achieve EVR, and 45% were SVR. Multivariate analysis identified low density lipoprotein cholesterol (LDL-C) (≥86mg/dl) and amino acid (aa) substitutions in HCV core region (Double wild type; arginine at aa 70 and leucine at aa 91) as independent and significant determinants of EVR. Furthermore, multivariate analysis identified LDL-C (≥86mg/dl), aa substitutions in core region (Double wild type), gender (male), ICG R15 (<10%), AST (<60IU/l) as determinants of SVR. In conclusion, LDL-C and aa substitutions in core region are important pretreatment predictors of response to treatment with PEG-IFN plus RBV in Japanese patients infected with genotype 1b.