- 著者
-
芥田 憲夫
鈴木 文孝
川村 祐介
八辻 寛美
瀬崎 ひとみ
鈴木 義之
保坂 哲也
小林 正宏
小林 万利子
荒瀬 康司
池田 健次
熊田 博光
- 出版者
- 一般社団法人 日本肝臓学会
- 雑誌
- 肝臓 (ISSN:04514203)
- 巻号頁・発行日
- vol.47, no.9, pp.450-451, 2006 (Released:2007-01-18)
- 参考文献数
- 5
- 被引用文献数
-
2
2
We evaluated 130 consecutive Japanese adults of HCV genotype 1b who received treatment with peginterferon (PEG-IFN) plus ribavirin (RBV) for 48 weeks, to investigate the pretreatment predictive factors of early virologic response (EVR) and sustained virological response (SVR). 75% of patients could achieve EVR, and 45% were SVR. Multivariate analysis identified low density lipoprotein cholesterol (LDL-C) (≥86mg/dl) and amino acid (aa) substitutions in HCV core region (Double wild type; arginine at aa 70 and leucine at aa 91) as independent and significant determinants of EVR. Furthermore, multivariate analysis identified LDL-C (≥86mg/dl), aa substitutions in core region (Double wild type), gender (male), ICG R15 (<10%), AST (<60IU/l) as determinants of SVR. In conclusion, LDL-C and aa substitutions in core region are important pretreatment predictors of response to treatment with PEG-IFN plus RBV in Japanese patients infected with genotype 1b.